{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:24:23Z","timestamp":1791584663235,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of iron deficiency and anemia in the setting of modern\u2010day maintenance immunosuppression in pediatric heart transplant (HTx) recipients is unclear. The primary aim was to determine the prevalence of iron deficiency (serum ferritin\u00a0&lt;\u00a030\u00a0ng\/mL\u00a0\u00b1\u00a0transferrin saturation\u00a0&lt;\u00a020%) and anemia per World Health Organization diagnostic criteria and associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center, cross\u2010sectional analysis of 200 consecutive pediatric HTx recipients\u00a0(&lt;21 years old) from 2005 to 2021. Data were collected at 1\u2010year post\u2010HTx at the time of annual protocol biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age at transplant was 3 years (IQR\u00a0.5\u201312.2). The median ferritin level was 32\u00a0ng\/mL with 46% having ferritin\u00a0&lt;\u00a030\u00a0ng\/mL. Median transferrin saturation (TSAT) was 22% with 47% having TSAT\u00a0&lt;\u00a020%. Median hemoglobin was 11\u00a0g\/dL with 54% having anemia. Multivariable analysis revealed lower absolute lymphocyte count, TSAT\u00a0&lt;\u00a020%, and estimated glomerular filtration rate\u00a0&lt;75\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> were independently associated with anemia. Ferritin\u00a0&lt;\u00a030\u00a0ng\/mL in isolation was not associated with anemia. Ferritin\u00a0&lt;\u00a030\u00a0ng\/mL may aid in detecting absolute iron deficiency while TSAT\u00a0&lt;\u00a020% may be useful in identifying patients with functional iron deficiency\u00a0\u00b1\u00a0anemia in pediatric HTx recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron deficiency and anemia are highly prevalent in pediatric HTx recipients. Future studies are needed to assess the impact of iron deficiency, whether with or without anemia, on clinical outcomes in pediatric HTx recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15367","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T14:39:25Z","timestamp":1716993565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of iron deficiency and anemia in pediatric heart transplant recipients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-8065","authenticated-orcid":false,"given":"David M.","family":"Newland","sequence":"first","affiliation":[{"name":"Department of Pharmacy Seattle Children's Hospital  Seattle Washington USA"},{"name":"School of Pharmacy University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn 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