{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:37:17Z","timestamp":1787960237675,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Describing risk factors and outcomes in kidney transplant recipients with oxalate nephropathy (ON) may help elucidate the pathogenesis and guide treatment strategies. We used a large single\u2010center database to identify patients with ON and categorized them into delayed graft function with ON (DGF\u2010ON) and late ON. Incidence density sampling was used to select controls. A total of 37 ON cases were diagnosed between 1\/2011 and 1\/2021. DGF\u2010ON (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) was diagnosed in 1.05% of the DGF population. Pancreatic atrophy on imaging (36.4% vs. 2.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and gastric bypass history (7.7% vs. 0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.06) were more common in DGF\u2010ON than with controls with DGF requiring biopsy but without evidence of ON. DGF\u2010ON was not associated with worse graft survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.98) or death\u2010censored graft survival (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.48). Late ON (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) was diagnosed after a mean of 78.2 months. Late ON patients were older (mean age 55.1 vs. 48.4 years; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), more likely to be women (61.7% vs. 37.5%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), have gastric bypass history (8.3% vs. 0.8%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and pancreatic atrophy on imaging (38.9% vs. 13.3%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). Late ON was associated with an increased risk of graft failure (HR 2.0; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.07) and death\u2010censored graft loss (HR 2.5; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.10). We describe two phenotypes of ON after kidney transplantation: DGF\u2010ON and late ON. Our study is the first to our knowledge to evaluate DGF\u2010ON with DGF controls without ON. Although limited by small sample size, DGF\u2010ON was not associated with adverse outcomes when compared with controls. Late ON predicted worse allograft outcomes.<\/jats:p>","DOI":"10.1111\/ctr.15368","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:59:29Z","timestamp":1718971169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Oxalate Nephropathy After Kidney Transplantation: Risk Factors and Outcomes of Two Phenotypes"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-2168","authenticated-orcid":false,"given":"Neetika","family":"Garg","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad C.","family":"Astor","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"},{"name":"Department of Population Health Sciences University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-7465","authenticated-orcid":false,"given":"Sandesh","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8230-3889","authenticated-orcid":false,"given":"Fahad","family":"Aziz","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjang","family":"Djamali","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Norby","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-8583","authenticated-orcid":false,"given":"Didier A.","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000690"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00661-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.07.017"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000340"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq065"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn697"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy271"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00684.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000001035"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-1-31"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198805000-00029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000188014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S397643"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530318666180328111302"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001464"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214940"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000748"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2016.04.004"},{"issue":"1","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.soard.2013.03.014","article-title":"Calcium Oxalate Supersaturation Increases Early After Roux\u2010en\u2010Y Gastric Bypass","volume":"10","author":"Agrawal V.","year":"2014","journal-title":"Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.06.021"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02288.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa254"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003134821998674"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000449128"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020121793"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-020-01197-4"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T05:13:25Z","timestamp":1719292405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ctr.15368"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15368","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15368"}}