{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:39:20Z","timestamp":1788925160921,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytomegalovirus infection (CMV) is a common complication after allogeneic hematopoietic stem cell transplantation (AHSCT). CMV infection increases transplantation costs; however, the extent of the financial burden may vary in different countries. This study aims to determine the clinical and economic impact of CMV infection in patients undergoing AHSCT in a middle\u2010income country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 150 adult and pediatric patients post\u2010AHSCT were included for analysis. In addition to incidence of CMV infections, data on graft versus host disease (GVHD) were also collected. Standard hospital charges for AHSCT and any additional transplantation\u2010related expenditure within 12 months were also retrieved in 104 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CMV infection, acute GVHD and chronic GVHD occurred in 38.7%, 60.7%, and 22.0% of patients, respectively. Patients with CMV infections had higher readmission rates compared to those who did not (67.2%\u00a0vs. 47.8%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020). Additional expenditure was seen in HLA\u2010haploidentical AHSCT and CMV infection (MYR11 712.25\/USD2 504.49; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001 and MYR5 807.24\/USD1 241.79; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.036), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This single\u2010center study demonstrated that patients who underwent HLA\u2010haploidentical AHSCT and subsequently developed CMV infection had higher transplantation expenditures compared to those who had matched\u2010related transplantation. Further studies should be conducted to evaluate if primary prophylaxis against CMV is cost\u2010effective, especially in patients who undergo HLA\u2010haploidentical AHSCT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15375","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:54:42Z","timestamp":1718970882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical and Economic Impact of CMV Infection in Allogeneic Hematopoietic Stem Cell Transplantation: Perspectives from a Middle\u2010Income Nation"],"prefix":"10.1111","volume":"38","author":[{"given":"Gin Gin","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-620X","authenticated-orcid":false,"given":"Thevambiga","family":"Iyadorai","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Yuhyi","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-7651","authenticated-orcid":false,"given":"Najihah","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Ariffin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine, Universiti Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-017-0180-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706640"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3616"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"151","article-title":"Seroprevalence of Cytomegalovirus, Toxoplasma and Parvovirus in Pregnancy","volume":"41","author":"Wong A.","year":"2000","journal-title":"Singapore Medical Journal"},{"issue":"2","key":"e_1_2_9_6_1","first-page":"294","article-title":"The Prevalence of Human Cytomegalovirus Seropositivity Among Blood Donors at the Unit of Blood Transfusion Medicine, Hospital Universiti Sains Malaysia","volume":"37","author":"Ahmed S. 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