{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:14:16Z","timestamp":1770470056109,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The increasing age of liver donors and transplant candidates, together with the growing prevalence of metabolic comorbidities, could impact the risk of vascular complications after liver transplantation. We enrolled a consecutive cohort of adult patients undergoing liver transplantation from 2012 to 2021 who had a blinded pathological assessment of atherosclerosis in the donor and recipient hepatic arteries (HA). Patients receiving partial or reduced grafts, retransplantation, or combined organ transplantation were excluded. The relationship between HA atherosclerosis and HA thrombosis after liver transplantation was evaluated using logistic regression in the whole study cohort and in a propensity score\u2010matched subpopulation. Among 443 eligible patients, 272 had a full pathological evaluation of the donor and recipient HA and were included in the study. HA atheroma was present in 51.5% of donors and in 11.4% of recipients. HA thrombosis occurred in 16 patients (5.9%), being more likely in patients who received a donor with HA atherosclerosis than in those without (10.7%\u00a0vs. 0.8%; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Donor HA atherosclerosis was an independent risk factor of HA thrombosis (OR\u00a0=\u00a017.79; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008), and this finding was consistent in the propensity score\u2010matched analysis according to age, sex, complex arterial anastomosis, and alcoholic liver disease (OR\u00a0=\u00a019.29; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007). Atheromatous disease in the recipient had no influence on the risk of HA thrombosis (OR\u00a0=\u00a01.70; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.55). In conclusion, patients receiving donors with HA atherosclerosis are at increased risk for HA thrombosis after liver transplantation. The evaluation of the donor graft vasculature could guide antiplatelet therapy in the postoperative period.<\/jats:p>","DOI":"10.1111\/ctr.15405","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T16:34:18Z","timestamp":1721579658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-4714","authenticated-orcid":false,"given":"Javier M.","family":"Zamora\u2010Olaya","sequence":"first","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Tejero\u2010Jurado","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma E.","family":"Ala\u00f1\u00f3n\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Prieto\u2010Torre","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rodr\u00edguez\u2010Medina","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"Montero","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de enfermedades hep\u00e1ticas y digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"S\u00e1nchez\u2010Fr\u00edas","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Department of Pathology Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Brice\u00f1o","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Department of HPB Surgery and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rub\u00e9n","family":"Ciria","sequence":"additional","affiliation":[{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Department of HPB Surgery and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Barrera","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de enfermedades hep\u00e1ticas y digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Poyato","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de enfermedades hep\u00e1ticas y digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"De la Mata","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de enfermedades hep\u00e1ticas y digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-2919","authenticated-orcid":false,"given":"Manuel L.","family":"Rodr\u00edguez\u2010Per\u00e1lvarez","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Liver Transplantation Hospital Universitario Reina Sof\u00eda  C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC)  C\u00f3rdoba Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de enfermedades hep\u00e1ticas y digestivas (CIBERehd)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02541.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.03.018"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23874"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200106150-00018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.12.032"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50098"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200103270-00014"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.22040"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00873-3"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.09.039"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.04.013"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12177"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1355"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01211.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004014"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.07.121"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002484"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012592"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-023-01951-1"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180562"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14629"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j909"},{"issue":"1","key":"e_1_2_13_25_1","first-page":"52","article-title":"Differential Effects of Moderate or Heavy Alcohol Consumption on Circulating Adhesion Molecule Levels","volume":"88","author":"Sacanella E.","year":"2002","journal-title":"Thrombosis and Haemostasis"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31772-0"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00822-y"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.15405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T15:21:10Z","timestamp":1726154470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.15405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/ctr.15405"],"URL":"https:\/\/doi.org\/10.1111\/ctr.15405","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2024-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15405"}}