{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:19:59Z","timestamp":1753877999941,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T00:00:00Z","timestamp":1721520000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Outcomes of deceased donor kidney transplant (DDKT) recipients from the same donor with donor\u2013recipient sex discordance have been studied with inconsistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult DDKT where both kidneys from the same donor occurred at our center in two different recipients of different sexes were included. Outcomes were analyzed separately for male and female donors, based on the concordance or discordance between donor\u2013recipient sex: Male\u2010male (M\u2010m) versus Male to female (M\u2010f) or vice versa, F\u2010f versus F\u2010m. Acute rejection (AR) and uncensored graft failure were primary outcomes of interest. The univariate and multivariate risks for AR and graft failure were conducted using the Cox proportional hazards model and log\u2010rank tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 130 donors, 84 male and 46 female fulfilled our selection criteria and were transplanted in 260 recipients. With respect to the concordant groups (M\u2010m or F\u2010f), sex discordance was not significantly associated with the risk of rejection in multivariate analysis (M\u2010f vs. M\u2010m HR 1.15 [0.53\u20132.53, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.72]; F\u2010m vs. F\u2010f HR 1.77 [0.71\u20134.39, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.23]). Sex discordance was also not significantly associated with graft failure in multivariate analysis. Interestingly, risk factors for AR differed among male donors and female donors. The higher calculated panel reactive antibodies (cPRA) and nonwhite recipients were at increased risk for AR in F\u2010m, but not in M\u2010f.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Donor\u2013recipient sex discordance was not significantly associated with AR or graft failure. Risk factors for AR may differ across male and female donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15409","type":"journal-article","created":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T16:24:09Z","timestamp":1721579049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes of Deceased Donor Kidney Recipients From the Same Donor Based on Donor\u2013Recipient Sex Discordance"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-9054","authenticated-orcid":false,"given":"Kurtis J.","family":"Swanson","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin 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