{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:09:27Z","timestamp":1788480567384,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010915","name":"American Society of Transplant Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Frailty and sarcopenia are associated with an increased risk of hospitalization and mortality in patients with end\u2010stage liver disease. The ability to identify frail patients at risk of adverse outcomes could help optimize liver transplant (LT) evaluations and pre\u2010transplant care. This study compared sarcopenia, via L3\u2010psoas muscle index (L3\u2010PMI), to frailty, via liver frailty index (LFI) and analyzed associated outcomes after liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of consecutive LT\u2010recipients with cross\u2010sectional abdominal\/pelvic imaging were reviewed over 5 years at a single transplant center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and twenty\u2010six patients underwent transplant during this study interval; 31% of patients were sarcopenic. Two hundred eight patients underwent LFI evaluation: 25% were frail, 59% were prefrail, and 16% were robust. Sarcopenic patients had higher LFI scores indicating greater frailty (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). Both sarcopenia and LFI\u2010frailty were associated with significantly higher MELD\u2010Na scores. Length of post\u2010LT hospital stay was increased in sarcopenic (mean 14\u00a0vs. nonsarcopenic 11 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and LFI\u2010frail patients (mean 13\u00a0vs. 10 prefrail, 8 robust, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). As a categorical variable, neither LFI\u2010frailty nor sarcopenia were significantly associated with reduced survival at 1\u2010year (robust 100%, prefrail 93.5%, frail 91.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.31) (nonsarcopenic 94.4%, sarcopenic 91.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.30). However, LFI score was significantly associated with mortality at 1\u2010year (OR 2.133, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Radiographic sarcopenia is a suitable proxy for in\u2010person frailty assessment as both L3\u2010PMI and LFI capture frail patients\u2019 pre\u2010LT. However, physical assessment with frailty better predicts 1\u2010year mortality post\u2010LT than the measurement of muscle mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15412","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T07:15:58Z","timestamp":1721891758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparing Functional Frailty and Radiographic Sarcopenia as Predictors of Outcomes After Liver Transplant"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5450-9564","authenticated-orcid":false,"given":"Sydney L.","family":"Olson","sequence":"first","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Department of Gynecology and Obstetrics Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-4684","authenticated-orcid":false,"given":"Praneet","family":"Polineni","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5423-9899","authenticated-orcid":false,"given":"William Alexander Henry","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-1370","authenticated-orcid":false,"given":"Avesh J.","family":"Thuluvath","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-9295","authenticated-orcid":false,"given":"Andres","family":"Duarte\u2010Rojo","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5526-8272","authenticated-orcid":false,"given":"Daniela P.","family":"Ladner","sequence":"additional","affiliation":[{"name":"Northwestern University Transplant Outcomes Research Collaborative (NUTORC) Comprehensive Transplant Center (CTC), Feinberg School of Medicine, Northwestern University  Chicago Illinois USA"},{"name":"Division of Organ Transplantation, Department of Surgery Northwestern Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.1.192"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2010.03.039"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12221"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23970"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12095"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23811"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-314"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002741"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23724"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12629"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23752"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24750"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23863"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23495"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12493"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"653","article-title":"Association Between Sarcopenia and Functional Status in Liver Transplant Patients","volume":"17","author":"Dolgin N. 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