{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:34:41Z","timestamp":1782603281624,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) is a herpesvirus linked to nine different human tumors and lymphoproliferative disorders. Immunosuppression promotes EBV\u2010driven malignancies. The most frequent EBV\u2010induced malignancies are lymphomas and nasopharyngeal carcinoma. By promoting smooth muscle proliferation, EBV can induce EBV\u2010associated smooth muscle tumors (EBV\u2010SMT). EBV\u2010SMT is a rare oncological entity for which no current guideline for diagnosis or management exists. Data on posttransplant EBV\u2010SMT (PT\u2010SMT) are scarce in kidney transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a national multicentric retrospective study and collected cases among transplantation centers in France. Kidney transplant recipients experiencing histologically proven PT\u2010SMT were included. We collected data on demographic characteristics of patient, history of kidney transplantation, history of PT\u2010SMT, evolution of graft function, and patient survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight patients were included. The median age at PT\u2010SMT diagnosis was 31 years (range 6.5\u201340). PT\u2010SMT occurred after a median delay of 37.8 months after transplantation (range 6\u2013175). PT\u2010SMT management consisted in immunosuppressive regimen minimization in all patients. Introduction of mTOR inhibitors was performed in two patients. Four patients (50%) needed chemotherapy. Surgical resection was performed in four patients. At last follow\u2010up after PT\u2010SMT diagnosis (median 33 months (range 17\u2013132)), five patients were considered in complete remission, and two patients had died. Two patients experienced graft rejection; two resumed dialysis (25%). All patients with available data presented with impaired graft function at last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PT\u2010SMT is a subacute and progressive disease during kidney transplantation. Even if the risk of developing PT\u2010SMT is low in kidney transplant recipients (0.07% in our cohort), PT\u2010SMT is associated with significant graft loss, possibly due to reduced immunosuppression. Developing guidelines could help transplantation teams better manage these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15424","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T10:20:49Z","timestamp":1723544449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epstein\u2013Barr Virus\u2010Associated Smooth Muscle Tumor After Kidney Transplantation: A French Multicenter Retrospective Study"],"prefix":"10.1111","volume":"38","author":[{"given":"Laur\u00e8ne","family":"Tardieu","sequence":"first","affiliation":[{"name":"Service de N\u00e9phrologie et H\u00e9modialyse H\u00f4pital Europ\u00e9en Georges Pompidou, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[{"name":"Service de Transplantation r\u00e9nale H\u00f4pital Universitaire 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