{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:43Z","timestamp":1753878583229,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development of connective tissue disease\u2010associated lung diseases (CTD\u2010LD) occurs in association with specific human leukocyte antigens (HLA). For CTD\u2010LD patients who require lung transplant, it is unknown whether utilization of donor organs expressing these same HLA impacts posttransplant outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Scientific Registry of Transplant Recipients, we assessed whether CTD\u2010LD lung transplant recipients in the United States have worse bronchiolitis obliterans (BOS)\u2010free survival based on the degree of donor HLA matching. This included overall degree of donor\u2010recipient HLA matching, donor\u2010recipient matching at DR loci, and recipient matching with specific donor HLA antigens associated with the development of pulmonary disease in their condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1413 patients with CTD\u2010ILD, highly HLA\u2010matched donor\u2010recipients did not have worse adjusted survival (hazard ratio [HR]\u00a0=\u00a00.93, 95% confidence interval [CI]\u00a0=\u00a00.58\u20131.51, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.77). Recipients who were fully matched at HLA DR did not have worse survival (HR\u00a0=\u00a00.82, 95% CI\u00a0=\u00a00.56\u20131.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.29). Finally, among individual CTD\u2010LD, including rheumatoid arthritis, systemic sclerosis, the idiopathic inflammatory myopathies, and systemic lupus erythematous, transplant with a donor expressing HLA antigens associated with lung manifestations in these conditions was not associated with worse BOS\u2010free survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among transplant recipients with CTD\u2010LD, HLA donor\u2010recipient matching, including at the DR loci, does not result in worse BOS\u2010free survival. Based on these findings, there is no reason to treat these as unacceptable antigens when considering donor offers for CTD\u2010LD candidates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15426","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T10:20:10Z","timestamp":1723544410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Donor\u2010Recipient Human Leukocyte Antigen Matching on Bronchiolitis Obliterans\u2010Free Survival Among Lung Transplant Recipients With Connective Tissue Diseases"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-5975","authenticated-orcid":false,"given":"Andrew M.","family":"Courtwright","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-4637","authenticated-orcid":false,"given":"Joshua M.","family":"Diamond","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Sandorfi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Hospital of the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary J.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688716"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435817"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.09.016"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06446-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217230"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00008014"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90013-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033133"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1862"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380216"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.2.201"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91235-M"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00915073"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200205000-00001"},{"key":"e_1_2_10_16_1","first-page":"1481","article-title":"HLA Markers for Susceptibility and Expression in Scleroderma","volume":"32","author":"Gladman D. 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