{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:17:24Z","timestamp":1792034244676,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Angiotensin II (ATII) maintains blood pressure via RAAS with a beneficial adverse effect profile versus catecholamines and phenylephrine. Head\u2010to\u2010head data comparing ATII to phenylephrine are lacking regarding renal allograft function, hemodynamic efficacy, and safety within the perioperative period of kidney transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, retrospective study included adult kidney transplant recipients who received continuous infusions of ATII or phenylephrine within a 24\u2010h perioperative period as a first\u2010line vasopressor according to an institutional algorithm. The primary endpoint was allograft function. Secondary endpoints were hemodynamic efficacy and adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 105 patients, there was no significant difference in IGF (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.545), SGF (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.557), or DGF (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.878) between patient cohorts. In the 34 patients with cold ischemia time (CIT) &gt; 14\u2010h, IGF was higher (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) and DGF (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.045) was lower in the ATII cohort versus phenylephrine. In all patients, ATII was associated with a decreased need for additional vasopressor agents (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Adverse effect profiles were similar between cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among kidney transplant recipients, ATII may be a suitable first\u2010line alternative compared with phenylephrine in the perioperative period for hypotension management with a reduced need for additional vasopressor support. Allograft benefits were observed in patients with prolonged CIT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.15432","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T19:44:15Z","timestamp":1724269455000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and Safety of Perioperative Angiotensin II Versus Phenylephrine as a First\u2010Line Continuous Infusion Vasopressor in Kidney Transplant Recipients"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0344-323X","authenticated-orcid":false,"given":"Lyra P.","family":"Beltran","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice University of Illinois Chicago College of Pharmacy Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2588-2356","authenticated-orcid":false,"given":"Jamie","family":"Benken","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice University of Illinois Chicago College of Pharmacy Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jou","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Illinois at Chicago College of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1120-6058","authenticated-orcid":false,"given":"Enrico","family":"Benedetti","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Transplantation University of Illinois at Chicago College of Medicine Chicago Illinois 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