{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:29:31Z","timestamp":1790458171468,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5R01MD007664"],"award-info":[{"award-number":["5R01MD007664"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK137111"],"award-info":[{"award-number":["R01DK137111"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Living donor kidney transplantation is the optimal treatment for end\u2010stage kidney disease; however, few living donor candidates (LDCs) who begin evaluation actually donate. While some LDCs are deemed medically ineligible, others discontinue for potentially modifiable reasons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>At five transplant centers, we conducted a prospective cohort study measuring LDCs\u2019 clinical and psychosocial characteristics, educational preparation, readiness to donate, and social determinants of health. We followed LDCs for 12 months after evaluation to determine whether they donated a kidney, opted to discontinue, had modifiable reasons for discontinuing, were medically ineligible, or had other recipient\u2010related reasons for discontinuing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2184 LDCs, 18.6% donated, 38.2% opted to or had modifiable reasons for discontinuing, and 43.2% were deemed ineligible due to medical or recipient\u2010related reasons. Multivariable analyses comparing successful LDCs with those who did not complete donation for modifiable reasons (<jats:italic>N<\/jats:italic>\u00a0=\u00a01241) found that LDCs who discussed donation with the recipient before evaluation (OR, 2.31; 95% CI, 1.54\u20133.46), had completed high school (OR, 2.01; 95% CI, 1.21\u20133.35), or were a \u201cclose relation\u201d to their recipient (OR, 1.89; 95% CI, 1.33\u20132.69) were more likely to donate. Conversely, LDCs who reported religion as important (OR, 0.55; 95% CI, 0.38\u20130.80), were Non\u2010White (OR, 0.70; 95% CI, 0.49\u20131.00), or had overall higher anxiety scores (OR, 0.92; 95% CI, 0.86\u20130.99) were less likely to donate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With fewer than a fifth of LDCs donating, developing programs to provide greater emotional support and facilitate open discussions between LDCs and recipients earlier may increase living donation rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15439","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:16:31Z","timestamp":1724789791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6873-5087","authenticated-orcid":false,"given":"Andrea M.","family":"Meinders","sequence":"first","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5813","authenticated-orcid":false,"given":"Edward A.","family":"Graviss","sequence":"additional","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital  Houston Texas USA"},{"name":"Department of Pathology and Genomic Medicine Houston Methodist Research Institute  Houston Texas USA"},{"name":"Academic Institute Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5059-4404","authenticated-orcid":false,"given":"Duc T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3364-4518","authenticated-orcid":false,"given":"Jonathan","family":"Daw","sequence":"additional","affiliation":[{"name":"Department of Sociology and Criminology Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4849","authenticated-orcid":false,"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Transplant Center St. Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5762-7881","authenticated-orcid":false,"given":"John Devin","family":"Peipert","sequence":"additional","affiliation":[{"name":"Department of Medical Social Sciences Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-4974","authenticated-orcid":false,"given":"Ahmed Osama","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital  Houston Texas USA"},{"name":"Academic Institute Houston Methodist Hospital  Houston Texas USA"},{"name":"J. 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Walter Jr. Transplant Center Houston Methodist Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5684-0613","authenticated-orcid":false,"given":"David A.","family":"Axelrod","sequence":"additional","affiliation":[{"name":"University of Iowa Organ Transplant Center University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-4803","authenticated-orcid":false,"given":"Francis L.","family":"Weng","sequence":"additional","affiliation":[{"name":"Renal and Pancreas Transplant Division Cooperman Barnabas Medical Center RWJ Barnabas Health  Livingston New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7799-0060","authenticated-orcid":false,"given":"Amy D.","family":"Waterman","sequence":"additional","affiliation":[{"name":"Department of Surgery Houston Methodist Hospital  Houston Texas USA"},{"name":"Academic Institute Houston Methodist Hospital  Houston Texas USA"},{"name":"J. 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