{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:42:40Z","timestamp":1789094560103,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T00:00:00Z","timestamp":1726012800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective and Background<\/jats:title><jats:p>Sinusoidal obstruction syndrome (SOS) is a life\u2010threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta\u2010analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03\u20131.77, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78\u20137.38, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09\u20132.21, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 16%) were risk factors for SOS after HSCT in children and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.15449","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T11:01:27Z","timestamp":1726052487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-4591","authenticated-orcid":false,"given":"Kai","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChenChen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Children's Hospital of Soochow University  Suzhou 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