{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:25:12Z","timestamp":1791228312283,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Successful early extubation (EE) after liver transplant (LT) has been shown to reduce intensive care unit (ICU) and hospital length of stay and infectious, vascular, and sedation\u2010related complications in adults. EE may not always be feasible in children, and many may require prolonged mechanical ventilation. Limited data exists regarding the candidacy of EE, risk factors, consequences, and hospital costs of delayed extubation (DE) in pediatric LT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review to investigate predictive factors and associated costs of EE and DE in infants and children after orthotopic LT at our institution between 2011 and 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 338 LT (median age 39 months, 54% females), 246 (73%) had EE (within 24 h of LT), while 27% had DE. Age &lt; 1 year (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0019), diagnosis of biliary atresia (0.02), abnormal pre\u2010LT echocardiogram (0.02), and patients with ongoing hospital admission before LT (0.0001) were independently associated with DE. Hospital costs were significantly (\u223c3\u2010fold) higher (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.0001) in the DE group. In addition, factors associated with increased total hospital costs were age &lt; 1 year and hospitalization before LT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EE post\u2010LT is feasible and merits a trial. The prevalence of DE though modest is associated with increased resource utilization and hospital costs. Children who can be extubated early and those at risk for DE can be identified pre\u2010operatively for optimal planning and allocation of resources.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.15472","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T09:37:49Z","timestamp":1728034669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Independent Risk Factors and Economic Burden Associated With Delayed Extubation Following Pediatric Liver Transplantation"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-1526","authenticated-orcid":false,"given":"Manpreet K.","family":"Virk","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Critical Care Medicine Texas Children's Hospital Baylor College of Medicine  Houston Texas 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Medicine Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Critical Care Medicine Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Critical Care Medicine Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Hosek","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital Quality Outcomes and Analytics  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Rossmann","family":"Beel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Anesthesiology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Schackman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Anesthesiology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Harpavat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Gastroenterology and Hepatology Texas Children's Hospital Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Goss","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Abdominal Transplantation and Hepatobiliary Surgery \u2013 Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreshwar S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Critical Care Medicine Texas Children's Hospital Baylor College of Medicine  Houston Texas 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