{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:00:06Z","timestamp":1782396006656,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Primary sclerosing cholangitis (PSC) has been shown to recur after liver transplantation (LT). Some studies have identified certain clinical and laboratory variables associated with an increased risk for recurrent PSC (rPSC) in Caucasians. Furthermore, de novo cholangiocarcinoma (CCA) has been reported anecdotally in patients with rPSC. This study aims to assess the prevalence of rPSC, identify its associated risk factors, and investigate the occurrence of de novo CCA in a highly admixed population from Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients submitted to LT for PSC enrolled in the Brazilian Cholestasis Study Group database were retrospectively reviewed for the occurrence of rPSC and de novo CCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six (58 males, mean age 32 \u00b1 13 years) patients with PSC underwent LT. After 90 (39\u2013154) months of follow\u2010up (FU), rPSC was observed in 29 (30%) subjects. There were no significant associations between rPSC and age, gender, concurrent or de novo inflammatory bowel disease, MELD score at the time of LT or allograft rejection. The only factor associated with an increased risk of disease recurrence was time after LT. Although survival was decreased in patients who developed rPSC, this difference was not significant. Only one female patient developed de novo CCA after rPSC, 11 years after LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recurrent PSC was observed in one\u2010third of PSC LT patients in Brazil and was associated with longer time after LT. Despite its frequency, rPSC was not associated with a higher risk of graft loss or a significant reduction in posttransplant survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70002","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:04:47Z","timestamp":1729602287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recurrence of Primary Sclerosing Cholangitis and De Novo Cholangiocarcinoma After Liver Transplantation: Results From the Brazilian Cholestasis Consortium"],"prefix":"10.1111","volume":"38","author":[{"given":"Paulo Lisboa","family":"Bittencourt","sequence":"first","affiliation":[{"name":"Hospital Portugu\u00eas Salvador Brazil"},{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus Jorge","family":"Nardelli","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00edsa Leite","family":"Barros","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Grossi Lopes","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais Belo Horizonte Brazil"},{"name":"Hospital da Pol\u00edcia Militar de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Luiz Rachid","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Raquel Benedita","family":"Terrabuio","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Alves","family":"Villela\u2010Nogueira","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia Gomes","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5178-8705","authenticated-orcid":false,"given":"Liana","family":"Codes","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Rotman","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Rocco","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einsten S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Eduardo","family":"Felga","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einsten S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Delgado","family":"Dotta","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrielly de Souza","family":"Martins","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Professor Edgard Santos Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Sampaio Costa","family":"Mendes","sequence":"additional","affiliation":[{"name":"Hospital de Base do Distrito Federal Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlone Cunha","family":"da Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie Bonfim","family":"Hyppolito","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Walter Cant\u00eddio Universidade Federal do Cear\u00e1 Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geisa Perez Medina","family":"Gomide","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade Federal do Tri\u00e2ngulo Mineiro Uberaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabelle Venturini","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Cassiano Ant\u00f4nio Moraes Vit\u00f3ria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatriz","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Ambulat\u00f3rio Municipal de Hepatites Virais de S\u00e3o Jos\u00e9 Dos Campos S\u00e3o Jos\u00e9 dos Campos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Alexandra Pontes","family":"Ivantes","sequence":"additional","affiliation":[{"name":"Hospital Nossa Senhora das Gra\u00e7as Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Chindamo","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Hospital Barra D\u00b4or \u2013 Rede D\u00b4or S\u00e3o Luiz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria Ferreira","family":"de Almeida e Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-3491","authenticated-orcid":false,"given":"Luciana Costa","family":"Faria","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Alves","family":"Couto","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32771"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201090175\u2010w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7746401"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15148"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(17)30693-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20106143.2003.00110.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20102277.2011.01324.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001725"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2021.101827"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004\u20102803.201900000\u201043"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjx008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw168"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290427"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010199811270\u201000006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2003.50143"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21394"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21313"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0898-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/830291"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13828"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24496"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24703"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11861-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20444"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21260"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21679"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1556\/imas.6.2014.1.2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24350"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1421705"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i43.4939"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478\u20103231.2006.01395.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03402.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000751"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23868"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22320"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.06.027"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31754-5"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.22015"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.12659\/aot.895936"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:41:28Z","timestamp":1748353288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/ctr.70002"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70002","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2023-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70002"}}