{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:33:28Z","timestamp":1768552408335,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Basiliximab is a high\u2010cost induction agent typically given as two doses in liver transplant recipients. This study evaluated renal outcomes in live\u2010donor liver transplant recipients (LDLTRs) with stable renal function at the time of transplant receiving one versus two doses of basiliximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively identified 231 adult LDLTR with a serum creatinine (SCr) &lt;1.5\u00a0mg\/dL on post\u2010transplant Day 5. The primary endpoint was a change in SCr from post\u2010transplant Days 5 to 30 between the groups. Secondary endpoints included incidence of acute kidney injury (AKI), liver rejection, and culture\u2010positive infections within 3 and 6 months of transplant. Basiliximab\u2010related cost savings were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median change in SCr from post\u2010transplant Days 5 to 30 was no different between the single\u2010dose or two\u2010dose groups (0.1 [IQR: \u22120.1\u20130.3] vs. 0.2 [IQR: \u22120.1\u20130.4], <jats:italic>p<\/jats:italic> = 0.08). Incidence of AKI was 56.9% in the two\u2010dose group versus 39.0% in the single\u2010dose group (<jats:italic>p<\/jats:italic> = 0.01). There was no difference in bacterial (<jats:italic>p<\/jats:italic> = 0.40), fungal (<jats:italic>p<\/jats:italic> = 0.59), or viral (<jats:italic>p<\/jats:italic> = 0.78) infections. Acute cellular rejection through 6 months post\u2010transplant was noted in 9.7% of patients receiving two doses and 6.3% in the single\u2010dose arm (<jats:italic>p<\/jats:italic> = 0.42). Basiliximab\u2010related cost savings in the single\u2010dose arm was \u223c$697 863.72 over 159 transplants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Single\u2010dose basiliximab appears to be safe and effective in place of two doses in LDLTR with stable renal function on post\u2010transplant Day 5. Utilization of a single basiliximab dose significantly reduced medication\u2010related costs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70006","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T13:06:00Z","timestamp":1729602360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Single Versus Two\u2010Dose Basiliximab Induction Therapy in Live\u2010Donor Liver Transplant"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7182-7967","authenticated-orcid":false,"given":"Benjamin N.","family":"Herrmann","sequence":"first","affiliation":[{"name":"Department of Pharmacy University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cody A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Pharmacy and Therapeutics University of Pittsburgh School of Pharmacy  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Humar","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen A.","family":"Shimko","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"\u201cLiving Donor Transplants in the U.S. by State \u201dOPTN accessed May 20 2023 https:\/\/optn.transplant.hrsa.gov\/data\/view\u2010data\u2010reports\/national\u2010data\/."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894\u2010023\u201000882\u20109"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2016.08.011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/children8070579"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13415"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495\u2010199957020\u201000006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7399\/fh.11036"},{"issue":"4","key":"e_1_2_11_9_1","article-title":"Single Dose Basiliximab Induction in Liver Transplant Recipients With Delayed CNI Initiation","volume":"18","author":"Salerno D.","year":"2018","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_11_10_1","unstructured":"\u201c2023 ASP Drug Pricing Files \u201dCMS.gov last modified June 09 2023 https:\/\/www.cms.gov\/medicare\/medicare\u2010part\u2010b\u2010drug\u2010average\u2010sales\u2010price\/2023\u2010asp\u2010drug\u2010pricing\u2010files."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0012.2246"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2021.62.2.164"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.02.052"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20618"},{"key":"e_1_2_11_15_1","unstructured":"Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR).OPTN\/SRTR 2021 Annual Data Report(U.S. Department of Health and Human Services Health Resources and Services Administration 2023). 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