{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:14:27Z","timestamp":1793124867306,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K02AG076883"],"award-info":[{"award-number":["K02AG076883"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG055781"],"award-info":[{"award-number":["R01AG055781"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG077888"],"award-info":[{"award-number":["R01AG077888"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F32AG082486"],"award-info":[{"award-number":["F32AG082486"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG076834"],"award-info":[{"award-number":["R01AG076834"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK114074"],"award-info":[{"award-number":["R01DK114074"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK120518"],"award-info":[{"award-number":["R01DK120518"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K24AI144954"],"award-info":[{"award-number":["K24AI144954"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Kidney transplant (KT) candidates often experience hospitalizations, increasing their delirium risk. Hospitalizations and delirium are associated with worse post\u2010KT outcomes, yet their relationship with pre\u2010KT outcomes is less clear. Pre\u2010KT delirium may worsen access to KT due to its negative impact on cognition and ability to maintain overall health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a prospective cohort of 2374 KT candidates evaluated at a single center (2009\u20132020), we abstracted hospitalizations and associated delirium records after listing via chart review. We evaluated associations between waitlist mortality and likelihood of KT with hospitalizations and hospitalized delirium using competing risk models and tested whether associations differed by gerontologic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median of 1.8 years after listing, 735 (31.0%) candidates had \u22651 hospitalizations. Candidates with less education, frailty, depressive symptoms, and lower extremity function impairment were more likely to be hospitalized. Hospitalization was associated with higher waitlist mortality (aSHR = 3.65, 95% CI: 2.99\u20134.45) and a lower likelihood of KT (aSHR = 0.74, 95% CI: 0.66\u20130.84). Among candidates who were hospitalized, 80 (11%) had \u22651 delirium episodes. Candidates who were older, frail, and impaired in lower extremity function were more likely to have delirium, which was associated with higher waitlist mortality (aSHR = 4.87, 95% CI: 3.42\u20136.93) and a lower likelihood of KT (aSHR = 0.45, 95% CI: 0.27\u20130.74). The association between hospitalization and KT differed by candidate age (p<jats:sub>interaction<\/jats:sub>\u00a0&lt;\u00a00.001), with those aged \u226565 having a 61% lower likelihood of KT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hospitalization and delirium are associated with worse pre\u2010KT outcomes and have serious implications on candidates\u2019 access to KT. Providers should work to reduce preventable instances of delirium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70018","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T12:59:25Z","timestamp":1730811565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hospitalization and Hospitalized Delirium Are Associated With Decreased Access to Kidney Transplantation and Increased Risk of Waitlist Mortality"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-6697","authenticated-orcid":false,"given":"Jane J.","family":"Long","sequence":"first","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-1306","authenticated-orcid":false,"given":"Jingyao","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Nalatwad","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-5740","authenticated-orcid":false,"given":"Yiting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-3431","authenticated-orcid":false,"given":"Nidhi","family":"Ghildayal","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-6626","authenticated-orcid":false,"given":"Emily A.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Schwartzberg","sequence":"additional","affiliation":[{"name":"Department of Psychiatry New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1209-2873","authenticated-orcid":false,"given":"Nicole","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Nephrology New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-5963","authenticated-orcid":false,"given":"Eric","family":"Oermann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-7408","authenticated-orcid":false,"given":"Michal","family":"Mankowski","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-2858","authenticated-orcid":false,"given":"Bruce E.","family":"Gelb","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Chanan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-4306","authenticated-orcid":false,"given":"Joshua L.","family":"Chodosh","sequence":"additional","affiliation":[{"name":"Department of Geriatrics New York University Grossman School of Medicine and Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-7433","authenticated-orcid":false,"given":"Aarti","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Surgery Johns Hopkins University Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-4801","authenticated-orcid":false,"given":"Dorry L.","family":"Segev","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"},{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-925X","authenticated-orcid":false,"given":"Mara A.","family":"McAdams\u2010DeMarco","sequence":"additional","affiliation":[{"name":"Department of Surgery New York University Grossman School of Medicine and Langone Health  New York New York USA"},{"name":"Department of Population Health New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001574"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14061"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004779"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001072"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1605501"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157\u2010020\u201001941\u20105"},{"key":"e_1_2_10_8_1","volume-title":"StatPearls [Internet]","author":"Lourdes Ram\u00edrez Echeverr\u00eda M.","year":"2024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018010064"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17176"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"issue":"8","key":"e_1_2_10_12_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) Examination","volume":"48","author":"Teng E. L.","year":"1987","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20104356(97)00060\u20107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060120024016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/9.3_Part_1.179"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895\u20104356(94)90129\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20106386(03)00415\u20103"},{"key":"e_1_2_10_20_1","unstructured":"National Cancer Institute GIS Portal for Cancer Research Accumulating Data to Optimally Predict Obesity Treament (ADOPT) Envionmental Domain Core Measures Data Files: Neighborhood Deprivation Index. Published online July 10 2023 accessed January 6 2024 https:\/\/gis.cancer.gov\/research\/files.html#soc\u2010dep."},{"key":"e_1_2_10_21_1","unstructured":"U.S. Census Bureau.2016\u20102020 American Community Survey 5\u2010year Public Use Microdata Samples[SAS Data file]. Published online 2020. accessed January 6 2024. Retrieved fromhttps:\/\/factfinder.census.gov\/faces\/nav\/jsf\/pages searchresults.xhtml?refresh=t."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2005.53120.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7501"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.10.153"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.4970"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001839"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004747"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000251780.01031.81"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080816"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.4975"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010119\u20106\u2010199309150\u201000005"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)60688\u20101"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472\u2010021\u201000326\u20101"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S152355"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.4081\/monaldi.2017.842"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.12067"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903043400901"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T15:04:30Z","timestamp":1732547070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/ctr.70018"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70018","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70018"}}