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The objective of this study was to analyze the influence of sociodemographic, lifestyle, physical, and psychological factors on sarcopenia and frailty risk in patients post\u2010HTx.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>133 patients post\u2010HTx (59.4% men, mean age 56.5 \u00b1 12.7 years) participated in this cross\u2010sectional study. The main outcomes were sarcopenia and frailty risk, and potential related predictors were comorbidities, time from transplantation, body mass index, sociodemographic factors, musculoskeletal pain, functional capacity, kinesiophobia, sleep problems, depression, physical activity, and diet quality. Multiple regression models were performed with all predictors, including polynomial regressions for predictors with a nonlinear relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The predictor variables explained 73.93% of frailty's variance. Functional capacity (with a nonlinear relationship) and diet quality were significant predictors of frailty risk, while diabetes and physical activity were marginally significant. In addition, the predictors explained 73.52% of sarcopenia's variance. Diabetes, functional capacity (with a nonlinear relationship), and kinesiophobia were significant predictors of sarcopenia risk, while pain intensity and diet quality were marginally significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multivariate analysis conducted on patients post\u2010HTx revealed that functional capacity was associated with both sarcopenia and frailty risk. Additionally, diet quality was a predictive factor of frailty, while diabetes and kinesiophobia were predictors of sarcopenia. These findings emphasize the importance of proper management to prevent frailty and sarcopenia, which share common associated factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70027","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:15:56Z","timestamp":1735650956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predicting Sarcopenia and Frailty Risk in Patients Post Heart Transplantation"],"prefix":"10.1111","volume":"39","author":[{"given":"Trinidad","family":"Sentandreu\u2010Ma\u00f1\u00f3","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Advanced Research Methods Applied to Quality of Life Promotion (ARMAQoL) Research Group University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Marques\u2010Sule","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy Physiotherapy in Motion, Multispeciality Research Group (PTinMOTION) University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Almenar\u2010Bonet","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Transplantation Unit Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Department of Medicine University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Methodology for the Behavioral Sciences, Advanced Research Methods Applied to Quality of Life Promotion (ARMAQoL) Research Group University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Hansen","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Center (REVAL), Faculty of Rehabilitation Sciences Hasselt University  Diepenbeek Belgium"},{"name":"Biomedical Research Institute (BIOMED), Faculty of Medicine and Life Sciences Hasselt University  Diepenbeek Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallav","family":"Deka","sequence":"additional","affiliation":[{"name":"College of Nursing Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"L\u00f3pez\u2010Vilella","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Failure and Transplantation Unit Hospital Universitario y Polit\u00e9cnico La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Klompstra","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Caring Sciences Linkoping University  Linkoping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-7695","authenticated-orcid":false,"given":"Felipe V. 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