{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T06:02:15Z","timestamp":1781503335526,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Calcineurin inhibitors (CNIs) are associated with long\u2010term complications after heart transplantation (HTx). Everolimus (EVR)\u2010based immunosuppression allows for CNI withdrawal. We used data from The Scandinavian heart transplant everolimus de novo study with early CNI avoidance (SCHEDULE) trial to assess whether health\u2010related quality of life (HRQoL) differed between patients on long\u2010term treatment with EVR versus a CNI\u2010based regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In SCHEDULE, we randomized 115 patients (mean age 51\u00a0\u00b1\u00a013 years, 27% women) to cyclosporine (CNI group; <jats:italic>n<\/jats:italic>\u00a0=\u00a059), or early introduction of EVR and cyclosporine withdrawal within 11 weeks of HTx (EVR group; <jats:italic>n<\/jats:italic>\u00a0=\u00a056). The primary endpoint was the glomerular filtration rate. We used the Short Form\u201036 (SF\u201036v2), the EuroQoL visual analogue scale (EQ VAS), and the Beck Depression Inventory (BDI) to assess HRQoL. We re\u2010evaluated the participants after 10\u201312 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010eight patients attended follow\u2010up at a median of 11 years after HTx. The SF\u201036 physical component summary score increased from 32\u00a0\u00b1\u00a010 pre\u2010HTx to 44\u00a0\u00b1\u00a012 11 years after HTx (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) in the EVR group and from 33\u00a0\u00b1\u00a09 to 44\u00a0\u00b1\u00a011 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) with CNI. The mental component summary score increased from 46\u00a0\u00b1\u00a012 to 53\u00a0\u00b1\u00a013 (EVR); <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 and from 38\u00a0\u00b1\u00a013 to 49\u00a0\u00b1\u00a013 (CNI); <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01. Similar improvements were observed regarding EQ\u2010VAS and the BDI. There were no significant between\u2010group differences for either measure of HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In heart transplant recipients, an EVR\u2010based immunosuppressive strategy resulted in similar long\u2010term improvements in HRQoL as treatment with a CNI\u2010based regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70028","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T09:28:05Z","timestamp":1732267685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Everolimus Versus Calcineurin Inhibitors on Quality of Life 10\u201312 Years After Heart Transplantation: The Results of a Randomized Controlled Trial (SCHEDULE Trial)"],"prefix":"10.1111","volume":"38","author":[{"given":"Ingelin","family":"Grov","sequence":"first","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Relbo","family":"Authen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-9293","authenticated-orcid":false,"given":"Satish","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Bergh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Institute of Medicine Sahlgrenska Academy University of Gothenburg, Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Rolid","sequence":"additional","affiliation":[{"name":"The Research Council of Norway  Lysaker Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Eiskj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"The Haemodynamic Lab The section for Heart Failure and Valvular Disease VO. Heart and Lung Medicine Department of Clinical Sciences Lund Cardiology Sk\u00e5ne University Hospital, Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einar","family":"Gude","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne K.","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Halden","sequence":"additional","affiliation":[{"name":"Novartis Norge AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Broch","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Centre and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-6641","authenticated-orcid":false,"given":"Lars","family":"Gullestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Oslo University Hospital Rikshospitalet  Oslo Norway"},{"name":"K.G.Jebsen Cardiac Research Centre and Center for Heart Failure Research Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the SCHEDULE investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.186"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.07.015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt-20-286"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-018-4745-8"},{"key":"e_1_2_10_7_1","first-page":"749","article-title":"Improvement in Quality of Life in Patients With Heart Failure Who Undergo Transplantation","volume":"15","author":"Grady K. 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