{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:32:19Z","timestamp":1781685139178,"version":"3.54.5"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myosteatosis is fat infiltration within skeletal muscle. The impact of myosteatosis on physical function and clinical outcomes in patients referred for liver transplantation (LT) is unclear. We explored associations between myosteatosis and sarcopenia, frailty, physical function, and pre\u2010 and early post\u2010LT outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Myosteatosis was assessed by computed tomography (CT) in 237 patients referred for LT (March 2018 to September 2022). Chi\u2010square\/Fishers exact tests and multivariable regression compared myosteatosis and sarcopenia, frailty (liver frailty index), physical function (short physical performance battery, SPPB); and associations with pre\u2010LT unplanned hospitalizations, post\u2010LT surgical complications (Clavien\u2013Dindo grade\u00a0\u2265\u00a03), and LT admission length of stay (LOS). Kaplan\u2013Meier and Cox\u2010proportional hazards models explored myosteatosis and time to LT and unplanned admission. Fine\u2013Gray model evaluated the competing risks of receiving an LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Myosteatosis was present in 74 (31%) patients. Patients with myosteatosis were 2.5 times (95% confidence interval [CI] 1.1\u20135.7, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) more likely to be frail, and 3.0 times (95% CI 1.6\u20135.6, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) more likely to have a poor physical function (SPPB\u00a0\u2264\u00a09\/12) than those without myosteatosis. Patients with myosteatosis versus those without were more likely to have a pre\u2010LT unplanned hospitalization (51% vs. 36%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03), but significance was lost after adjusting for age, sex, Model for End\u2010stage Liver Disease (MELD), and the presence of hepatocellular carcinoma. Myosteatosis did not impact the likelihood of receiving an LT (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.39), post\u2010LT complications (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.93), or LOS in intensive care unit (ICU) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.66) or hospital (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.34).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Myosteatosis is prevalent in patients referred for LT and is associated with impaired physical function. Using existing CTs to assess myosteatosis in practice may help identify physically compromised patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70034","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:12:45Z","timestamp":1733220765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Myosteatosis Is Associated With Frailty and Poor Physical Function in Patients Undergoing Liver Transplant Evaluation: A Cohort Study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5332-6520","authenticated-orcid":false,"given":"Heidi E.","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Nutrition &amp; Dietetics Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Queensland Liver Transplant Service Facility is Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Faculty of Medicine The University of Queensland  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-8381","authenticated-orcid":false,"given":"Melita","family":"Andelkovic","sequence":"additional","affiliation":[{"name":"Queensland Liver Transplant Service Facility is Princess Alexandra Hospital  Brisbane QLD Australia"},{"name":"Faculty of Medicine The University of Queensland  Brisbane QLD Australia"},{"name":"Department of Gastroenterology &amp; 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