{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:26:31Z","timestamp":1753878391835,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ME 3696\/3\u20101"],"award-info":[{"award-number":["ME 3696\/3\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021828","name":"German Academic Exchange Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a leading indication for liver transplantation (LT), but also occurs after LT. The prevalence of de novo MASLD (dnMASLD) after LT, based on both surveillance (svLbx) and indication biopsies (indLbx), is unknown. Furthermore, the impact of the distinct cardiometabolic risk factors on histological disease activity has not been assessed. We aimed to evaluate the prevalence of dnMASLD and the association between the cardiometabolic risk factors and histological disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective single\u2010center study in a LT cohort with indLbx and svLbx. Patients with NAFLD before LT were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 249 patients who underwent either svLbx or indLbx. Forty\u2010eight (19.2%) had either dnMASLD (<jats:italic>n<\/jats:italic> = 26\/249, 10.4%) or metabolic dysfunction associated steatohepatitis (dnMASH) (<jats:italic>n<\/jats:italic> = 22\/249, 8.8%). Although dnMASLD\/dnMASH was more frequent in indLbx (35.1%, <jats:italic>p<\/jats:italic> &lt; 0.01), still 16.5% of patients with svLbx had dnMASLD\/dnMASH. While overweight (<jats:italic>p<\/jats:italic> &lt; 0.01) and diabetes (<jats:italic>p<\/jats:italic> = 0.01) were more frequent in patients with dnMASH, only overweight was associated with histological disease activity in the multivariate analysis. No impact of dnMASLD on the overall survival was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While dnMASLD is more frequent in patients with indLBX, it also occurs in 16.5% of patients without signs of graft dysfunction. Overweight has the strongest impact on histological disease activity and should be monitored carefully after LT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70039","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T09:29:42Z","timestamp":1732267782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overweight Impacts Histological Disease Activity of De Novo Metabolic Dysfunction\u2010Associated Steatotic Liver Disease After Liver Transplantation"],"prefix":"10.1111","volume":"38","author":[{"given":"Alejandro","family":"Campos\u2010Murguia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Hepatology Infectious Diseases and Endocrinology Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Guetzlaff","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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