{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:10Z","timestamp":1753878010248,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There has been significant concern about coronavirus disease 2019 (COVID\u201019) among transplant recipients, particularly those who are highly immunosuppressed. Several studies have analyzed the impact of COVID\u201019 on different solid organ transplant patients. However, few isolated case reports of COVID\u201019 in intestinal and multivisceral transplant (ITx and MVTx) recipients are available in the literature. We report the first single\u2010center study evaluating the clinical course and outcome of COVID\u201019 in ITx\/MVTx recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult patients (age \u2265 18 years) with confirmed cases of COVID\u201019 between February 2020 and February 2024 were included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve of the 67 (17.9%) ITx\/MVTx recipients followed at our center had COVID\u201019. Seven patients (58%) were female, and the median age at diagnosis was 47 years (range: 31\u201368 years). The average time from transplantation to COVID\u201019 was 89 months (range: 14\u2013215 months). Nine patients (75%) required hospitalization; three of them were admitted to the intensive care unit (ICU) and required ventilator support. One patient had COVID\u201019 on two different occasions. Treatment modalities consisted of monoclonal antibody treatment (<jats:italic>n<\/jats:italic> = 5), of antiviral therapy (<jats:italic>n<\/jats:italic> = 4), and steroid monotherapy (<jats:italic>n<\/jats:italic> = 1). Three patients received combination therapy. Three patients (25%) developed irreversible respiratory failure and died after prolonged ventilator use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggested a possible increase in the incidence of COVID\u201019 in ITx and MVTx recipients with an unchanged mortality rate despite the use of vaccines and new therapeutic modalities. Further multicenter studies are needed to analyze the real impact of COVID\u201019 on this unique population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70065","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:29:54Z","timestamp":1735558194000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving Impact of COVID\u201019 on Intestinal Transplant Recipients: A Single\u2010Center Experience"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-9940","authenticated-orcid":false,"given":"Colin","family":"Powers","sequence":"first","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brielle","family":"Corrente","sequence":"additional","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Joyce","sequence":"additional","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Stein","sequence":"additional","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-0440","authenticated-orcid":false,"given":"Ajai","family":"Khanna","sequence":"additional","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-6915","authenticated-orcid":false,"given":"Fernanda P.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Infectious Diseases University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-9978","authenticated-orcid":false,"suffix":"Jr.","given":"Ruy J.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Gastro\u2010Intestinal Rehabilitation and Transplant Center \u2010 GIRTC Starzl Transplantation Institute University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Department of Surgery University of Pittsburgh  Pittsburgh Pennsylvania 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Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T11:37:27Z","timestamp":1737891447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ctr.70065"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70065","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"2024-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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