{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:25Z","timestamp":1753878505082,"version":"3.41.2"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of donor kidneys with acute kidney injury (AKI) aims to expand the organ pool, but uncertainty remains regarding their outcomes across different Kidney Donor Profile Index (KDPI) groups and preservation methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed 108\u00a0160 deceased donor kidney transplants from the OPTN database, focusing on adult recipients of kidneys from donors with or without AKI between December 2014 and December 2022. Propensity matching was used for each KDPI group (1\u201320, 21\u201359, 60\u201384, and 85\u2013100), comparing donors with AKIN stages 0\u20131 to AKIN stages 2\u20133. Cox proportional hazards analysis assessed graft survival by AKIN stages and preservation type.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of AKIN stage 2\u20133 kidneys significantly increased over the study period. AKIN does not negatively impact graft survival in the KDPI 1\u201320 group and is linked to improved survival in KDPI 21\u201359 and 60\u201384. In the KDPI 85\u2013100 group, AKIN stage 2\u20133 shows a trend toward increased graft failure. Pump preservation reduces delayed graft function (DGF) across most KDPI groups but does not consistently improve long\u2010term survival, except in KDPI 85\u2013100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transplantation with AKIN stage 2\u20133 kidneys is viable, but outcomes vary by KDPI group. Tailored guidelines should consider transplant center capabilities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70078","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T17:43:58Z","timestamp":1736531038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tailoring Kidney Transplant Strategies: Unraveling the Impact of Acute Kidney Injury and Preservation Methods Across Different Strata of Kidney Risk"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4714-3725","authenticated-orcid":false,"given":"Daniel M.","family":"Kaufman","sequence":"first","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-0012","authenticated-orcid":false,"given":"James D.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Washington  Seattle Washington USA"},{"name":"Clinical and Bio\u2010Analytics Transplant Laboratory (CBATL) Division of Transplantaiton University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3279-2930","authenticated-orcid":false,"given":"Nicolae","family":"Leca","sequence":"additional","affiliation":[{"name":"Clinical and Bio\u2010Analytics Transplant Laboratory (CBATL) Division of Transplantaiton University of Washington  Seattle Washington USA"},{"name":"Division of Nephrology Department of Medicine University of Washington Medical Center  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-9719","authenticated-orcid":false,"given":"Ramasamy","family":"Bakthavatsalam","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Washington  Seattle Washington USA"},{"name":"Clinical and Bio\u2010Analytics Transplant Laboratory (CBATL) Division of Transplantaiton University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-737X","authenticated-orcid":false,"given":"Lena","family":"Sibulesky","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Washington  Seattle Washington USA"},{"name":"Clinical and Bio\u2010Analytics Transplant Laboratory (CBATL) Division of Transplantaiton University of Washington  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05021107"},{"key":"e_1_2_10_3_1","unstructured":"OPTN\/SRTR 2022 Annual Data Report: Introduction. Hennepin Healthcare Research Institute and the United Network for Organ Sharing. Published for the U.S. Department of Health and Human Services Health Resources and Services Administration."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac620b"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5713"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249000"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.047"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11232"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004597"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14279"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.20.083"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123871"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072311"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802289"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072311"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0551"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc7759"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract13040086"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/00273171.2011.568786"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010022\u201002777\u20109"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T11:36:38Z","timestamp":1737891398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ctr.70078"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70078","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70078"}}