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This descriptive study aimed to analyze post\u2010transplant survival in the recent era compared to earlier periods and examine the pharmacogenetics of related immunosuppressants. Data from all recipients who underwent heart transplants from 1987 to 2021 were retrospectively retrieved from the electronic medical record. The genotypes of relevant pharmacogenes were analyzed in recipients who were alive during the enrollment period. Kaplan\u2013Meier analysis revealed improved overall survival rates in the recent era compared to the past. Dilated cardiomyopathy was identified as the most common pretransplant diagnosis, while infection remained the leading cause of mortality. In conclusion, the findings demonstrate significant advancements in the quality of heart transplantation in Thailand. Future studies are warranted to explore the correlation between pharmacogenetic variations identified in this study and subsequent clinical outcomes, with a focus on genetic\u2010guided treatment to optimize patient care.<\/jats:p>","DOI":"10.1111\/ctr.70092","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T07:14:13Z","timestamp":1738134853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights"],"prefix":"10.1111","volume":"39","author":[{"given":"Siwaporn","family":"Manomaisantiphap","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Pharmacology Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasawat","family":"Boon\u2010yasidhi","sequence":"additional","affiliation":[{"name":"Faculty of 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