{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:14Z","timestamp":1753878014562,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>An increasing number of elderly patients are undergoing either primary kidney transplantation (PrKT) or retransplantation (ReKT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010center retrospective cohort study of all deceased donor KTs (DDKTs) performed in elderly patients (age \u226565 years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From December 2004 through August 2022, we performed 668 DDKTs in elderly patients including 39 ReKTs and 629 PrKTs. Mean donor age was lower in the ReKT group (44\u00a0\u00b1\u00a017 ReKT vs. 54\u00a0\u00b1\u00a013 years PrKT), as was KDPI (58\u00a0\u00b1\u00a024\u00a0vs. 74\u00a0\u00b1\u00a021% PrKT, both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). A total of 44% of ReKT patients had a cPRA level above 50% compared to 10.3% PrKT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Rates were comparable between groups for primary nonfunction (2.6% ReKT vs. 3.7% PrKT) and delayed graft function (23% ReKT vs. 32% PrKT, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.29). Five\u2010year patient (55.2% ReKT vs. 74.3% PrKT, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and graft survival rates (GSRs, 55.2% ReKT vs. 64.7% PrKT, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.32) were higher in the PrKT group. Death with functioning graft (DWFG) occurred in 59% of ReKT versus 37.4% of PrKT patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and accounted for 79.3% ReKT and 65.3% PrKT graft losses. Death\u2010censored GSRs were not different (62.5% ReKT vs. 68.3% PrKT, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly recipients of deceased donor ReKTs have a higher risk of DWFG, but death\u2010censored outcomes are comparable to age\u2010matched PrKT recipients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70129","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:31:44Z","timestamp":1741707104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kidney Retransplantation in the Elderly: Are the Benefits Worth the Risks?"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-5604","authenticated-orcid":false,"given":"Syed S.","family":"Mujtahedi","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-2617","authenticated-orcid":false,"given":"Colleen L.","family":"Jay","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Sakhovskaya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Reeves\u2010Daniel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Mena\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Nephrology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily K. E.","family":"McCracken","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan C.","family":"Farney","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-7974","authenticated-orcid":false,"given":"Giuseppe","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jigish","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Cabrales","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-094X","authenticated-orcid":false,"given":"Robert J.","family":"Stratta","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation Atrium Health Wake Forest Baptist  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001618"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.01.012"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16463"},{"key":"e_1_2_8_5_1","unstructured":"Organ Procurement and Transplantation Network\u2014NationalData accessed 10\/08\/2024 https:\/\/optn.transplant.hrsa.gov\/data\/view\u2010data\u2010reports\/national\u2010data\/."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01530219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0426-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003842"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12992"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.01.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000831"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16786"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17081"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15170"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-024-00438-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ac620b"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200211150-00014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04150418"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13185"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14628"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2020.12.005"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.01.032"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13029"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000611"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12463"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4172\/2167-7182.1000324"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b4acfb"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T23:32:40Z","timestamp":1742945560000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/ctr.70129"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70129","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}