{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:42Z","timestamp":1787014062767,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tacrolimus is highly effective at preventing allograft rejection and prolonging survival after lung transplantation. However, erratic pharmacokinetics may limit efficacy and predispose to greater adverse effects. We conducted a prospective, open\u2010label trial of lung transplant recipients who underwent early conversion (within 30 days) to LCP tacrolimus (LCPT,\n                    <jats:italic>n<\/jats:italic>\n                    = 40) and compared first\u2010year outcomes to an historical control of patients who remained on immediate\u2010release tacrolimus (IRT,\n                    <jats:italic>n<\/jats:italic>\n                    = 24). Subjects were converted 1:1 from IRT to LCPT. The first dose of LCPT overlapped with the last morning dose of IRT. Conversion to LCPT occurred at a median of 17.5 [IQR 12\u201325] days. The conversion dose ratio was 1.0 mg:mg [IQR 0.75\u20131.50] at 14 days. At 1 year, there were no differences between LCPT and IRT in the incidence of biopsy\u2010proven (12.5% vs. 25.0%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.30) or clinically treated (20.0% vs. 25.0%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.64) acute cellular rejection. However, the severity of any biopsy\u2010proven rejection was significantly higher in the IRT cohort (27.5% vs. 54.2%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03). Although not achieving statistical significance, de novo donor\u2010specific antibodies were more commonly observed in the LCPT group (20.0% vs. 4.2%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.14). Despite this, the incidence of antibody\u2010mediated rejection (7.5% vs. 0.0%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.29) and early\u2010onset chronic lung allograft dysfunction (7.5% vs. 9.1%,\n                    <jats:italic>p<\/jats:italic>\n                    = 1.00) were similar. The incidence of chronic kidney disease stage 4 or greater at 1\u2010year was similar (7.5% vs. 12.5%,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.66). In conclusion, early conversion to LCPT was feasible and similarly efficacious to IRT in a cohort of lung transplant recipients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : ClinicalTrials.gov identifier: NCT04420195\n                  <\/jats:p>","DOI":"10.1111\/ctr.70159","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T13:30:57Z","timestamp":1745847057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Early Conversion to LCP\u2010Tacrolimus (ENVARSUS XR) to Immediate\u2010Release Tacrolimus in Lung Transplant Recipients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-1917","authenticated-orcid":false,"given":"Tyler C.","family":"Lewis","sequence":"first","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Hotchkis","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-0537","authenticated-orcid":false,"given":"Adrian","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Lamaina","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avital","family":"Stiefel","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Ohanian","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Schnier","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care, and Sleep Medicine Department of Medicine NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lesko","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya","family":"Rudym","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake G.","family":"Natalini","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Angel","sequence":"additional","affiliation":[{"name":"Transplant Institute NYU Langone Health  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.07.020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1618567"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(05)80003-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.04.022"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000181161.60638.fa"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317230-000000000-00000"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.01.404"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.05.028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14723"},{"key":"e_1_2_9_11_1","article-title":"Improved Bioavailability of MELTDOSE Once\u2010Daily Formulation of Tacrolimus (LCP\u2010Tacro) With Controlled Agglomeration Allows for Consistent Absorption Over 24 Hrs: A Scintigraphic and Pharmacokinetic Evaluation [Abstract]","volume":"13","author":"Nigro V. G. A.","year":"2013","journal-title":"American Journal of Transplantation"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0282-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12035"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182962cc1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13935"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002348"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15561"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.10.017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.3.9607099"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.01.1223"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000863"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.10.024"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12770"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14487"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14941"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.602764"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhlto.2023.100043"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020379"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2012.18.7.527"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488611794480043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2007.00693.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12581"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2020.01.108"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2107"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:50:41Z","timestamp":1748260241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/ctr.70159"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70159","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,28]]},"assertion":[{"value":"2024-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70159"}}