{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:20Z","timestamp":1753878020094,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>To compare pressure\u2010volume (PV) derivative variables between HT patients and healthy controls and to assess their impact on long\u2010term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center retrospective study, HT patients surviving their first post\u2010HT year with left ventricular ejection fraction (LVEF) \u226550%, absence of allograft vasculopathy, and rejection were enrolled. PV variable surrogates were measured by transthoracic echocardiography and compared with healthy controls. The endpoint was cardiovascular mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1985 to 2015, 345 patients were enrolled. Arterial elastance (Ea) and left ventricular end\u2010systolic elastance (Ees) were higher in HT recipients than in healthy controls (4.03\u00a0vs. 1.65, <jats:italic>p<\/jats:italic> &lt; 0.0001 and 6.75\u00a0vs. 2.47, <jats:italic>p<\/jats:italic> &lt; 0.0001, respectively), while ventricular arterial coupling (VAC) was similar between the two groups (0.66\u00a0vs. 0.59, <jats:italic>p<\/jats:italic> = 0.105). After a median of 11.3\u2010year follow\u2010up, 59 (17%) HT recipients died. VAC was not significantly associated with cardiac mortality (<jats:italic>p<\/jats:italic> = 0.074). Survival was lower in HT recipients with Ea &gt; 4\u00a0mmHg\/mL\/m<jats:sup>2<\/jats:sup> and Ees \u2264 6.75\u00a0mmHg\/mL\/m<jats:sup>2<\/jats:sup>, and both were independently associated with mortality risk after adjustment (Ea &gt; 4\u00a0mmHg\/mL\/m<jats:sup>2<\/jats:sup>: HR 2.25 [95% CI 1.38\u20133.66], <jats:italic>p<\/jats:italic> = 0.013; Ees \u2264 6.75\u00a0mmHg\/mL\/m<jats:sup>2<\/jats:sup>: HR 3.70 [95% CI 1.95\u20137.06], <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In HT recipients surviving the first year after transplantation with normal LVEF, high Ea, and low Ees values were independently associated with poorer outcomes in long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70178","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:49:39Z","timestamp":1747147779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Left Ventricular\u2010Vascular Interaction on Long\u2010Term Outcome After Heart Transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-280X","authenticated-orcid":false,"given":"Mattia","family":"Corian\u00f2","sequence":"first","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences and Public Health, University Hospital Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5129-5190","authenticated-orcid":false,"given":"Nicola","family":"Pradegan","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Cardiac 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Pathological Anatomy Unit, Department of Cardiac Thoracic, Vascular Sciences and Public Health, University of Padova  Padua Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-9629","authenticated-orcid":false,"given":"Antonio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Cardiac Thoracic, Vascular Sciences, and Public Health, University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9011-1625","authenticated-orcid":false,"given":"Chiara","family":"Tessari","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Cardiac Thoracic, Vascular Sciences, and Public Health, University of Padua  Padua 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