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Among its characteristics, tacrolimus has a high inter\u2010 and intrapatient variability. Recently, tacrolimus intrapatient variability (Tac\u2010IPV) has been proposed as a useful biomarker to predict outcomes in different types of solid organ transplantation. This work includes a systematic review of the literature that evaluates Tac\u2010IPV influence on solid organ transplantation outcomes from inception to September 18, 2024. Although there are several publications assessing the influence of Tac\u2010IPV in transplantation, we found that there is a lack of consensus regarding which is the best measure to evaluate Tac\u2010IPV. Moreover, the ideal post\u2010transplantation period for evaluating this biomarker has not been established so far. Different cut\u2010off points have been proposed, especially in adult kidney transplantation, where most of the studies have been carried out, but these cut\u2010off values may not be applicable to other transplantation modalities. This work includes a description of the main findings of different studies in an attempt to state what the current knowledge on the topic is in different solid organ transplantation modalities.<\/jats:p>","DOI":"10.1111\/ctr.70197","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:30:49Z","timestamp":1749724249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tacrolimus Intrapatient Variability as a Biomarker in Solid Organ Transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-6951","authenticated-orcid":false,"given":"Rita","family":"Nogueiras\u2010\u00c1lvarez","sequence":"first","affiliation":[{"name":"Clinical Pharmacology, Osakidetza Basque Health Service Galdakao\u2010Usansolo University Hospital, Galdakao  Bizkaia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Mar","family":"Garc\u00eda\u2010Saiz","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Service Marqu\u00e9s de Valdecilla University Hospital  Santander Cantabria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls","author":"Araya A. 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