{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T01:37:59Z","timestamp":1781487479225,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recommendations remain unclear between a shorter or extended CMV prophylaxis duration in donor seropositive\/recipient seronegative (D+\/R\u2013) heart transplant recipients. The purpose of our study is to evaluate the effectiveness of a short (less than 145 days) versus extended (145 days or more) duration of CMV prophylaxis with ganciclovir (GCV)\/valganciclovir (VGCV) for prevention of CMV viremia in this high\u2010risk patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted of adult (age \u2265 18 years) CMV D+\/R\u2013 heart transplantation recipients who received intravenous (IV) GCV or oral (PO) VGCV after transplant for CMV prophylaxis. CMV viremia\/disease, time to CMV viremia\/disease, hospitalizations, and mortality within the first year of transplant were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 D+\/R\u2013 heart transplant recipients were included in this study, with 28 recipients receiving short duration prophylaxis and 27 recipients receiving extended duration. The median (IQR) duration of therapy for the short and extended duration groups was 76 (69\u2013100) and 189 (168\u2013278) days, respectively. There were similar rates of CMV viremia (35.7%\u00a0vs. 48.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.35) and CMV disease (10.7%\u00a0vs. 11.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.96) between the short and extended duration prophylaxis groups. The outcomes of time to CMV from transplant, CMV hospitalization, and mortality were also similar between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the present study, no difference was observed in the incidence of CMV viremia within 1 year between short versus extended duration of GCV\/VGCV prophylaxis in CMV D+\/R\u2013 heart transplant recipients. Prospective studies with a larger sample size may be needed to confirm this finding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70223","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:30:20Z","timestamp":1751452220000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Short versus Extended Valganciclovir Prophylaxis in Donor\u2010Positive Recipient\u2010Negative Mismatched Heart Transplant Recipients: An Observational Study"],"prefix":"10.1111","volume":"39","author":[{"given":"Alainee","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Pharmacy Memorial Hermann \u2013 Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-849X","authenticated-orcid":false,"given":"Phillip","family":"Weeks","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Hermann \u2013 Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ty","family":"Drake","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Hermann \u2013 Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoosh","family":"Sobhanian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Memorial Hermann \u2013 Texas Medical Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriram","family":"Nathan","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation University of Texas Health Science Center at Houston, Center for Advanced Heart Failure  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Patarroyo\u2010Aponte","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation University of Texas Health Science Center at Houston, Center for Advanced Heart Failure  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2290-2964","authenticated-orcid":false,"given":"Igor","family":"Gregoric","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation University of Texas Health Science Center at Houston, Center for Advanced Heart Failure  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Kar","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiopulmonary Therapies and Transplantation University of Texas Health Science Center at Houston, Center for Advanced Heart Failure  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"About Cytomegalovirus and Congenital CMV Infection(Centers for Disease Control and Prevention 2020). Accessed July 26 2023.https:\/\/www.cdc.gov\/cmv\/overview.html."},{"issue":"3","key":"e_1_2_9_3_1","first-page":"381","article-title":"Infection After Heart Transplantation: A Multi\u2010Institutional Study. Cardiac Transplant Research Database Group","volume":"13","author":"Miller L. W.","year":"1994","journal-title":"Journal of Heart and Lung Transplantation"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399\u20100012.2003.00152.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20106143.2003.00140.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14982"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13512"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0b013e3181ff1493"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010152\u201012\u2010201006150\u201000003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1600\u20106143.2003.00308.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2004.00571.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000204048.90367.97"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12896"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13255"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:09:42Z","timestamp":1753265382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/ctr.70223"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70223","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70223"}}