{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:54:34Z","timestamp":1754153674198,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508905","2022YFA1103300"],"award-info":[{"award-number":["2023YFC2508905","2022YFA1103300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470214","82270227","82070189"],"award-info":[{"award-number":["82470214","82270227","82070189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cytokine release syndrome (CRS) after graft infusion under anti\u2010thymocyte globulin (ATG)\u2013based haploidentical (haplo)\u2010hematopoietic stem cell transplantation is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to explore the clinical implications of CRS after graft infusion under ATG\u2010based haplo\u2010SCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>We retrospectively analyzed the data of 259 patients who underwent haplo\u2010SCT, graded CRS, and evaluated transplant outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CRS occurred in 103\/259 (39.8%) of the recipients. Severe CRS (Grades 3\u20135) was not observed. Fever was the most common manifestation (89.3%), and all cases occurred only after peripheral blood stem cell (PBSC) infusion. According to the multivariable analysis, being older than 55 years (OR 2.486 (1.124\u20135.496), <jats:italic>p<\/jats:italic> = 0.024), having higher CRP levels during conditioning (OR 3.011 (95% CI, 1.766\u20135.134), <jats:italic>p<\/jats:italic> &lt; 0.001), and receiving PBSC as the sole stem cell source (OR 2.478 (95% CI, 1.077\u20135.700), <jats:italic>p<\/jats:italic> = 0.033) could predict the development of CRS, whereas an HCT\u2010CI score \u2265 2 was an independent risk factor for Grade 2 CRS (OR 4.259 (95% CI, 1.515\u201311.969, <jats:italic>p<\/jats:italic> = 0.006)). The 3\u2010year OS was not significantly different between the two groups, with 79% (95% CI, 61\u201397) for Grade 2 CRS and 85% (95% CI, 80\u201390) for Grade 0\u20131 CRS (<jats:italic>p<\/jats:italic> = 0.288). The GRFS rates in the two groups were 69% (95% CI, 49\u201390) and 67% (95% CI, 60\u201374), respectively (<jats:italic>p<\/jats:italic> = 0.644).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that CRS is common in patients receiving ATG\u2010based haplo\u2010SCT and does not affect survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ctr.70242","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:03:21Z","timestamp":1753085001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, Risk Factors, and Impact on Transplant Outcomes of Cytokine Release Syndrome After Infusion of Haploidentical Stem Cells With Anti\u2010Thymocyte Globulin"],"prefix":"10.1111","volume":"39","author":[{"given":"Feng\u2010Mei","family":"Zheng","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Kong","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng\u2010Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Ting","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Xia","family":"Fu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University Beijing 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