{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:07:42Z","timestamp":1783944462024,"version":"3.55.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cancer is among the major causes of death after heart transplant (HTx). Risk factors for cancer occurrence in this setting are not well established. This was a retrospective observational study of patients who underwent HTx between 2006 and 2019 and were followed up until May 2024. Clinical variables possibly associated with cancer were assessed with univariable and multivariable analyses. Survival analysis was carried out drawing Kaplan Meier curves and a Cox regression with time\u2010varying covariates were performed to overcome the immortal\u2010time\u2010bias. Three\u2010hundred\u2010thirty\u2010five HTx recipients were included, of whom 42 (12.5%) developed cancer after a median of 6.3 years. In univariable analysis, older age at HTx, smoking history, alcohol use, male sex, ischemic heart disease before HTx, use of cyclosporine rather than tacrolimus, and increased length of follow\u2010up were associated with cancer. Upon\u00a0multivariable analysis, ischemic heart disease (OR 2.70 [1.19\u20136.11],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.017) and length of follow\u2010up (OR 1.02 [1.00\u20131.04],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.007) were independently associated with cancer occurrence. Cox regression revealed a higher risk of mortality among patients with cancer (HR 3.400, [2.026\u20135.709],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). HTx recipients with prior ischemic cardiomyopathy and a longer survival time after transplant show a higher risk of developing cancer. Cancer significantly impairs post\u2010transplant survival.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70243","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T08:55:20Z","timestamp":1753433720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conditions Associated With the Onset of Cancer After Heart Transplant: Longitudinal Study in 335 Recipients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-9180","authenticated-orcid":false,"given":"Fabian","family":"Patauner","sequence":"first","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-7943","authenticated-orcid":false,"given":"Filomena","family":"Boccia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-0730","authenticated-orcid":false,"given":"Silvia","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"},{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5584-7890","authenticated-orcid":false,"given":"Giuliana","family":"Autiero","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"},{"name":"Department of Internal Medicine Azienda Ospedale Universit\u00e0 Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5903-9191","authenticated-orcid":false,"given":"Raffaella","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-4292","authenticated-orcid":false,"given":"Lorenzo","family":"Bertolino","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Mattucci","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplants A.O.R.N. Ospedali dei Colli \u2010 Ospedale Monaldi  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pinto","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine &amp; Transplants A.O.R.N. Ospedali dei Colli \u2010 Ospedale Monaldi  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Andini","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine &amp; Transplants A.O.R.N. Ospedali dei Colli \u2010 Ospedale Monaldi  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7949-7771","authenticated-orcid":false,"given":"Cristiano","family":"Amarelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplants A.O.R.N. 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