{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:07:57Z","timestamp":1783944477800,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2508905"],"award-info":[{"award-number":["2023YFC2508905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103300"],"award-info":[{"award-number":["2022YFA1103300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470214"],"award-info":[{"award-number":["82470214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270227"],"award-info":[{"award-number":["82270227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070189"],"award-info":[{"award-number":["82070189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300245"],"award-info":[{"award-number":["82300245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blast percentage is crucial for myelodysplastic syndrome (MDS) diagnosis and risk stratification, but its role is now less prominent due to comprehensive genetic\u2010based scoring systems like the Molecular International Prognostic Scoring System (IPSS\u2010M). Originally, blast percentage was an independent categorical variable for prognosis, but in the IPSS\u2010M, it is treated as a continuous variable. We hypothesize that blast percentage should still hold categorical value within genetic\u2010based systems like the IPSS\u2010M, especially for predicting transplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 225 MDS patients posttransplantation were retrospectively studied for blast percentage and genetic impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified significant disparities in relapse rates, with a marked contrast between the MDS with increased blasts (IBs) group and the MDS with low blasts group, achieving statistical significance. Intriguingly, within the IB cohort, a pronounced divergence in relapse rates was noted between the high and low risk subgroups within the IB\u20101 group, but not the IB\u20102 group. Furthermore, the combined model of blast percentage and IPSS\u2010M demonstrated enhanced prognostic performance, with a higher C\u2010index and lower information criteria than IPSS\u2010M alone, indicating the synergistic prognostic value of these two factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study underscores the significant value of integrating blast percentage as a categorical variable with the IPSS\u2010M for posttransplant prognosis in MDS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70258","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T05:43:48Z","timestamp":1753767828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Blast Percentage on Posttransplant Outcomes of Patients With Myelodysplastic Syndromes: A Retrospective Analysis Within the IPSS\u2010M Framework"],"prefix":"10.1111","volume":"39","author":[{"given":"Zhong\u2010Shi","family":"Lyu","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qian","family":"Sun","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University  Beijing 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