{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:07:44Z","timestamp":1783944464919,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Late\u2010onset severe pneumonia (LOSP) is one of the most important causes of mortality after allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). The influenza virus is a frequent viral pathogen in patients receiving allo\u2010HSCT, accounting for at least 30% of all respiratory viral infections. We aimed to identify the clinical characteristics and outcomes of influenza\u2010associated LOSP after allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled 23 patients who underwent allo\u2010HSCT at the Peking University Institute of Hematology and were subsequently diagnosed with influenza\u2010associated LOSP. Survival analysis was conducted via the Kaplan\u2012Meier method. Potential risk factors for survival and mortality following influenza\u2010associated LOSP were evaluated through univariate and multivariate Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the patients, 39.1% (\n                      <jats:italic>n<\/jats:italic>\n                      = 9) died following influenza\u2010associated LOSP. The median time from allo\u2010HSCT to influenza infection was 269 days (range 100\u20133979 days), and the median time from the onset of influenza symptoms to influenza\u2010associated LOSP was 5 days (range 0\u201338 days). The most common clinical manifestations were fever (95.7%), cough (56.5%), and expectoration (34.8%). After antiviral therapy, the median time for the influenza virus to turn negative was 11 days (range, 4\u201334 days). The 100\u2010day cumulative incidence of influenza\u2010associated LOSP\u2010related mortality was 30.9% (95% CI 11.3%\u201350.5%). The probability of overall survival at 100 days after influenza\u2010associated LOSP was 59.1% (95% CI 41.5%\u201384.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents the first comprehensive analysis of the clinical characteristics and outcomes associated with influenza\u2010related LOSP following allo\u2010HSCT. Additionally, our findings highlight the treatment strategies and prognostic factors associated with influenza\u2010associated LOSP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70287","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T14:28:52Z","timestamp":1755700132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcomes of Influenza\u2010Associated Late\u2010Onset Severe Pneumonia After Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7510-7202","authenticated-orcid":false,"given":"Yuewen","family":"Wang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leqing","family":"Cao","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-1081","authenticated-orcid":false,"given":"Lanping","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1253-7465","authenticated-orcid":false,"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing 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and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengrong","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies Peking University People's Hospital Peking University Institute of Hematology Peking University  Beijing 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