{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:48:58Z","timestamp":1779122938986,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elexacaftor\/tezacaftor\/ivacaftor (ETI) has dramatically changed the landscape of cystic fibrosis (CF) care, including in those who require lung transplantation. The objectives of the study were to describe the cohort demographics and outcomes of primary lung transplant recipients before and after the availability of ETI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a descriptive study of lung transplants performed at the Toronto Lung Transplant Program for CF during two time periods: 2019 (pre\u2010ETI era) and 2021\u20132023 (post\u2010ETI era). All subjects were referred from the Adult CF program at St. Michael's Hospital, Toronto. Data were obtained from chart review and the Toronto Lung Transplant database. The Kaplan\u2013Meier method was used to estimate survival probability at 1 year post\u2010transplant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 22 lung transplants performed in 2019 (19 [86.4%] primary and 3 [13.6%] re\u2010transplants) compared to 11 lung transplants (8 [72.7%] primary and 3 [27.3%] re\u2010transplants) in the post\u2010ETI era. In primary transplant recipients, median age was 29.4 years (Range 18.6\u201367.6 years) in 2019 compared to 30.0 years (Range 19.1\u201364.0 years) in 2021\u20132023. In the post\u2010ETI era, none of the individuals had a deltaF508 variant, compared to 84% in 2019. One\u2010year survival probability was lower in the post\u2010ETI era (62.5%\u00a0vs. 84.2%, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lung transplant recipients in the post\u2010ETI era were more complex with high\u2010risk characteristics and had worse post\u2010transplant outcomes. This study highlights the importance of further investigation to better understand the impact of ETI on transplant referral patterns, recipient characteristics, and post\u2010transplant outcomes in the CF population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70317","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:28:00Z","timestamp":1758900480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Changing Transplant Landscape in the Era of Elexacaftor\/Tezacaftor\/Ivacaftor: A Word of Caution"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-2741","authenticated-orcid":false,"given":"Julie","family":"Semenchuk","sequence":"first","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Toronto Lung Transplant Program, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza","family":"Tuff\u2010Gordon","sequence":"additional","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiayi","family":"Ma","sequence":"additional","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Sykes","sequence":"additional","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Canada  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-0024","authenticated-orcid":false,"given":"Meghan","family":"Aversa","sequence":"additional","affiliation":[{"name":"Toronto Lung Transplant Program, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Toronto Lung Transplant Program, University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Tullis","sequence":"additional","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne L.","family":"Stephenson","sequence":"additional","affiliation":[{"name":"Adult CF Program, St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital  Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management and Evaluation, University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0858"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.01.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202011-4153OC"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210394"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(24)00114-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02437-2022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2023.03.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.06.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.06.017"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"61","article-title":"Lung Transplantation for End\u2010Stage Cystic Fibrosis Before and After the availability of Elexacaftor\u2010Tezacaftor\u2010Ivacaftor, Germany, 2012\u20102021","author":"Ringshausen F. 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