{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:13:20Z","timestamp":1790108000020,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of kidney vascular pathology on transplant outcomes remains poorly understood, particularly under specific donor conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective single\u2010center study analyzed 837 deceased donor kidney transplants. Based on baseline vascular histology, the kidneys were categorized into two groups: minimal vascular disease (Group 0,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0637) and significant vascular disease (Group 1,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0200). Five\u2010year graft survival and 6\u2010 and 12\u2010month kidney function were evaluated, along with subgroup analyses of various donor characteristics. Propensity score matching was used to adjust for confounding factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Recipients of kidneys with significant vascular disease showed worse 5\u2010year overall graft survival (64.6%\u00a0vs. 80.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0002) and death\u2010censored graft survival (85.6%\u00a0vs. 91.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0126). These differences persisted after propensity score matching. The impact was most pronounced in hypertensive donors (53.4%\u00a0vs. 84.9%) and diabetic donors (52.3%\u00a0vs. 69.0%). Circulatory death donors showed immediate adverse effects, while brain death donors demonstrated delayed deterioration. Kidneys with significant vascular disease exhibited lower glomerular filtration rates at follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline vascular disease in deceased donor kidneys has a significant impact on transplant outcomes, independent of clinical risk factors. These findings support the incorporation of vascular histological assessment into donor evaluation to enhance risk stratification and optimize post\u2010transplant management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70332","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T15:25:38Z","timestamp":1758900338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline Vascular Pathology in Deceased Donor Kidneys: Differential Impact on Transplant Outcomes by Donor Type"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-4936","authenticated-orcid":false,"given":"Junichiro","family":"Sageshima","sequence":"first","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naeem","family":"Goussous","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Loseth","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Alghannam","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4277-893X","authenticated-orcid":false,"given":"Ling\u2010Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophoclis","family":"Alexopoulos","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Surgery University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang\u2010Yu","family":"Jen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Davis Health  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000746"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13213"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181ca7e9b"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.5.705"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20102277.2008.00681.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04150418"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12699"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.08.022"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890\u2010200006150\u201000030"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15357"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31818776b2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016121330"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012111081"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13929"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02394.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.17167"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199412150-00010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100012.2011.01401.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02370.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14676"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052891"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000820"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09170819"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.461"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620\u2010019\u201000638\u20107"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.07610713"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:12:31Z","timestamp":1761289951000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/ctr.70332"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70332","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"2025-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70332"}}