{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:17:45Z","timestamp":1761290265848,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>This study aimed to provide updated nationwide data on outcomes in heart transplantation for amyloid cardiomyopathy (ACM) compared with other cardiomyopathy etiologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>United Network for Organ Sharing data for patients over 18 who underwent heart transplant for ACM, and other cardiomyopathies including DCM, ICM, RCM, and CHD were reviewed from 2001 through 2022. The data were analyzed with a propensity score\u2010matched analysis comparing ACM patients with transplant for the cardiomyopathies to measure primary outcomes, including 5\u2010year, 10\u2010year, and all\u2010cause mortality accounting for differences at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 21 457 heart transplant recipients who met eligibility criteria, there was a 100% increase in the number of heart transplants for ACM from 2010 to 2020 (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The unadjusted mortality did not differ significantly among ACM, DCM, ICM, RCM, and CHD groups, and 5\u2010year mortality was comparable between ACM and DCM patients. ACM patients had a significantly lower incidence of postoperative stroke (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.044), and risk factors for ACM transplant mortality were identified as mechanical ventilation at the time of transplant (HR: 3.8,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.023) and older donor age (HR: 1.1,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The number of heart transplants for ACM has increased in recent years, and overall outcomes in these ACM transplants have been similar compared to those for other cardiomyopathies. Despite historical concerns regarding poor prognosis and amyloid recurrence, carefully screened ACM patients can benefit from heart transplantation. Further research and optimization of ACM patient eligibility criteria alongside investigation of concurrent adjunctive therapies could optimize treatment of ACM with heart transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70343","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:32:47Z","timestamp":1760005967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heart Transplantation for Amyloid Cardiomyopathy Has Comparable Outcomes With Other Etiologies: The UNOS Database"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-0974","authenticated-orcid":false,"given":"Nicholas","family":"Steudel","sequence":"first","affiliation":[{"name":"Department of Surgery Lahey Clinic  Burlington Massachusetts USA"},{"name":"UMass Chan Medical School Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias P.","family":"Doulamis","sequence":"additional","affiliation":[{"name":"Department of Surgery Lahey Clinic  Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivam","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Department of Surgery Lahey Clinic  Burlington Massachusetts USA"},{"name":"UMass Chan Medical School Lahey Hospital and Medical Center  Burlington Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aspasia","family":"Tzani","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart and Vascular Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai Mount Sinai Beth Israel  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Asleh","sequence":"additional","affiliation":[{"name":"Heart Institute Hadassah University Medical Center Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilmi","family":"Alnsasra","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases and Health Sciences Research and the William J. Von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Tepetes","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Avgerinos","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Department Onassis Cardiac Surgery Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9670","authenticated-orcid":false,"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics National Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.01.170"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10741\u2010017\u20109601\u2010Z"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOODADVANCES.2018016402"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2022.08.002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2019.04.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.11.019"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318187"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.85.2.202"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AHJ.2021.02.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2004.08.025"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.31083\/rcm25831"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102012\u201012\u2010473066"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2003.08.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.04.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.01.425"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.12.013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0b013e3181f10edb"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.05.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.11.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.124.012663"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.01.024"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.022"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:12:55Z","timestamp":1761289975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/ctr.70343"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70343","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"type":"print","value":"0902-0063"},{"type":"electronic","value":"1399-0012"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70343"}}