{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:39:36Z","timestamp":1793108376400,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Semaglutide, a glucagon\u2010like peptide\u20101 receptor agonist, has demonstrated efficacy for weight loss and glycemic control in patients with obesity and type 2 diabetes mellitus, but data are limited\u00a0for patients with end\u2010stage kidney disease on dialysis. We\u00a0examined the weight loss efficacy and safety of semaglutide when prescribed\u00a0to patients on dialysis to improve transplant candidacy and activation status. We conducted a retrospective chart review of 36 patients on dialysis who were prescribed semaglutide through a metabolic clinic between September 2021 and December 2023. Outcomes included weight loss efficacy, safety, and change in waitlist status at\u00a01 year. Patients achieved\u00a0a mean total body weight loss\u00a0of 7.8% (SD 6.1). Of patients who were ineligible for transplant due to elevated body mass index, 48.2% achieved waitlist activation after successful weight loss. Treatment\u2010limiting gastrointestinal side effects occurred in 16.7% of patients. Patients on peritoneal dialysis (PD, 30.8%) versus hemodialysis (8.7%) discontinued therapy more frequently. In a single\u2010center cohort, patients who received semaglutide experienced significantly greater weight loss and increased rates of waitlist activation compared with a lifestyle\u2010only intervention. Semaglutide was generally well\u2010tolerated. Prospective studies should examine whether patients on PD experience severe GI side effects more frequently on semaglutide.<\/jats:p>","DOI":"10.1111\/ctr.70344","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T16:49:36Z","timestamp":1760201376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bridging the Gap to Waitlist Activation: Semaglutide's Weight Loss Efficacy and Safety in Patients With Obesity on Dialysis Seeking Kidney Transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1313-8335","authenticated-orcid":false,"given":"Francis G.","family":"Wade","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Internal Medicine SSM Health\/Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9423-4849","authenticated-orcid":false,"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Hospital Transplant Center Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3534-6283","authenticated-orcid":false,"given":"David","family":"Turk","sequence":"additional","affiliation":[{"name":"School of Medicine Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-3662","authenticated-orcid":false,"given":"Kyleigh","family":"Kirbach","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Department of Internal Medicine SSM Health\/Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6778-4633","authenticated-orcid":false,"given":"Taylor","family":"Knobloch","sequence":"additional","affiliation":[{"name":"Department of Nutrition &amp; Dietetics SSM Health Saint Louis University Hospital  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8547-5643","authenticated-orcid":false,"given":"Mark","family":"Schnitzler","sequence":"additional","affiliation":[{"name":"SSM Health Saint Louis University Hospital Transplant Center Saint Louis University  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-7269","authenticated-orcid":false,"given":"Kamran","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Internal Medicine Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-0500","authenticated-orcid":false,"given":"Wing\u2010Kin","family":"Syn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Internal Medicine Saint Louis University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Physiology, Faculty of Medicine and Nursing University of Basque Country UPV\/EHU  Vizcaya Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7655-9375","authenticated-orcid":false,"given":"Vidya A.","family":"Fleetwood","sequence":"additional","affiliation":[{"name":"Division of Transplantation Michael E. DeBakey Department of Surgery Baylor Medical College  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2413258"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00174-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_11_7_1","unstructured":"United States Renal Data System 2022 USRDS Annual Data Report: Epidemiology of kidney disease in the United States (National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases 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