{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:00:44Z","timestamp":1790179244079,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is a common but poorly characterized complication in heart transplant (HT) recipients due to limited use of renal damage markers, such as albuminuria. Our aim is to determine CKD prevalence based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria, assess CKD risk stratification according KDIGO guidelines, and describe the use of cardiorenal protective drugs in a contemporary HT cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional, single\u2010center study was conducted in stable HT recipients under follow\u2010up in 2023. CKD was defined as an estimated glomerular filtration rate (eGFR)\u00a0&lt;\u00a060\u00a0mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      (using CKD\u2010EPI) and\/or albumin\u2010to\u2010creatinine ratio (UACR)\u00a0\u2265\u00a030\u00a0mg\/g. Patients were stratified into KDIGO risk categories based on eGFR and UACR thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 207 patients (median age 65\u00a0years; 29% women; median time since transplant: 8\u00a0years), the median eGFR was 51\u00a0mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , with 58.9% having an eGFR\u00a0&lt;\u00a060\u00a0mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      and median UACR was 45 (8\u2013173)\u00a0mg\/g, with 57% showing elevated UACR. The prevalence of CKD was 79.2%, with 36 (17.4%) patients exhibiting elevated UACR despite an eGFR\u00a0\u2265\u00a060\u00a0mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      . A total of 23.7%, 19.8%, 21.7%, and 34.8% were classified as low, moderate, high, and very high KDIGO risk categories, respectively. Among patients meeting the CKD criteria, 37.2% were on ACEi\/ARBs and 26.2% on SGLT2i.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CKD is highly prevalent in HT recipients, with UACR improving diagnostic accuracy. Over half of patients fell into high\u2010risk KDIGO categories, indicating substantial CKD severity. However, the underuse of renal\u2010protective therapies highlights the need for better alignment with current clinical guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70347","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:31:15Z","timestamp":1765377075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Albuminuria in Diagnosing and Stratifying Kidney Disease in Heart Transplant Recipients: A KDIGO Criteria\u2010Based Analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-8371","authenticated-orcid":false,"given":"Pedro","family":"Caravaca\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Heart Failure and Heart Transplant Unit Institut Cl\u00ednic Cardiovascular (ICCV) Hospital Cl\u00ednic Universitat De Barcelona  Barcelona Spain"},{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Salazar Rodriguez","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Unit Institut Cl\u00ednic Cardiovascular (ICCV) Hospital Cl\u00ednic Universitat De Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-9083","authenticated-orcid":false,"given":"Jos\u00e9 Jes\u00fas","family":"Broseta","sequence":"additional","affiliation":[{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Nephrology and Renal Transplantation Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Laboratori Experimental de Nefrologia i Trasplantament (LENIT)  Barcelona Spain"},{"name":"Department of Medicine Universitat De Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-9925","authenticated-orcid":false,"given":"Eduard","family":"Sol\u00e9 Gonzalez","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Unit Institut Cl\u00ednic Cardiovascular (ICCV) Hospital Cl\u00ednic Universitat De Barcelona  Barcelona Spain"},{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Castel","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Unit Institut Cl\u00ednic Cardiovascular (ICCV) Hospital Cl\u00ednic Universitat De Barcelona  Barcelona Spain"},{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Centro De Investigaci\u00f3n Biom\u00e9dica En Red Enfermedades Cardiovasculares (CIBERCV)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-3658","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Heart Failure and Heart Transplant Unit Institut Cl\u00ednic Cardiovascular (ICCV) Hospital Cl\u00ednic Universitat De Barcelona  Barcelona Spain"},{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-6911","authenticated-orcid":false,"given":"Elena","family":"Cuadrado\u2010Pay\u00e1n","sequence":"additional","affiliation":[{"name":"Institut D'investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona Spain"},{"name":"Nephrology and Renal Transplantation Hospital Cl\u00ednic de Barcelona  Barcelona Spain"},{"name":"Laboratori Experimental de Nefrologia i Trasplantament (LENIT)  Barcelona 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