{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:15:11Z","timestamp":1773501311299,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Following kidney transplantation (KTx), episodes of hyperkalemia are common and effectively treated with sodium zirconium cyclosilicate (SZC, Lokelma) or patiromer (PAT, Veltassa). The presence of SZC\/PAT in the gastrointestinal tract may, if radio dense, influence the interpretation of lumbar spine (LS) dual\u2010energy x\u2010ray absorptiometry (DXA)\u2010scans. We investigated the effect with\/without PAT\/SZC in KTx on LS DXA readings.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A prospective, single\u2010center study of KTx recipients in need of potassium\u2010lowering therapy was performed. All participants performed two LS DXA\u2010scans, the first after at least 3 days of SZC\/PAT treatment and the second after a 2\u2010week washout.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighteen KTx patients (8 SZC, 10\u00a0g\/day vs. 10 PAT, 8.4\u00a0g\/day) were included and provided two valid DXA\u2010scans (mean age 63 \u00b1 12 years, 12 males). The change in LS BMD determinations in the SZC group was 2.48 \u00b112.21%, while there was no change in the PAT group, \u20100.25 \u00b1 2.28%. The absolute root mean squared difference (RMSD) change was 0.102 \u00b1 0.084 g\/cm\n 2<\/jats:sup>\n and 0.021 \u00b10.013\u00a0g\/cm\n 2<\/jats:sup>\n after SZC and PAT washout, respectively (\n p<\/jats:italic>\n = 0.008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In KTx, treatment with SZC, but not PAT, significantly influenced the DXA\u2010scan interpretation of the LS region. After a 2\u2010week washout period, SZC interference was without clinical implications on DXA\u2010scans.<\/jats:p>\n <\/jats:sec>\n \n Summary<\/jats:title>\n The potassium lowering drug sodium zirconium cyclosilicate (Lokelma) is radiopaque and therefore acts as a confounder on DXA interpretations in kidney transplant recipients. Patiromer (PAT, Veltassa) has no such effect.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ctr.70352","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T15:06:00Z","timestamp":1760454360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Potassium\u2010Binders on the Interpretation of Bone Mineral Density Following Kidney Transplantation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1769","authenticated-orcid":false,"given":"Anders","family":"\u00c5sberg","sequence":"first","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"},{"name":"Department of Pharmacy University of Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Midtvedt","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn Petter","family":"Lindahl","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hege","family":"Pihlstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Transplantation Medicine Oslo University Hospital Rikshospitalet Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Section of Specialized Endocrinology Department of Endocrinology Oslo University Hospital Rikshospitalet Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Godang","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology Department of Endocrinology Oslo University Hospital Rikshospitalet Oslo Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-017-6767-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1178140"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10235523"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2020.05.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2010.01.121"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410126"},{"key":"e_1_2_10_8_1","unstructured":"R core Team.R: A language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria.https:\/\/www.R\u2010project.org\/.2018."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.03.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2018.07.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2005.10.003"},{"issue":"5","key":"e_1_2_10_12_1","first-page":"197","article-title":"Measurement of Bone by Dual\u2010Photon Absorptiometry (DPA) and Dual\u2010Energy X\u2010Ray Absorptiometry (DEXA)","volume":"77","author":"Mazess R. B.","year":"1988","journal-title":"Annales Chirurgiae Et Gynaecologiae"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199209000-00006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-021-00607-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2023.2284839"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"724","article-title":"A Comparison of Lateral Versus Anterior\u2010posterior Spine Dual Energy X\u2010Ray Absorptiometry for the Diagnosis of Osteopenia","volume":"78","author":"Finkelstein J. S.","year":"1994","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:12:35Z","timestamp":1761289955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/ctr.70352"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70352","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-07-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70352"}}