{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:23:37Z","timestamp":1789629817348,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:00:00Z","timestamp":1761868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to assess the impact of CYP3A5 genotype\u2010based LCP tacrolimus (tac) versus weight\u2010based dosing among adult kidney transplant recipients. This was a retrospective longitudinal matched cohort analysis. From February 2021 to June 2023, LCP tac was dosed using standard weight\u2010based dosing. Starting in June 2023, genotype\u2010based dosing was used; 148 patients were included (74 in each arm). Baseline characteristics were well balanced between the groups, except for age (control 46\u00a0\u00b1\u00a014\u00a0vs. 52\u00a0\u00b1\u00a014 years,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01); 32% were females, 36% were African American, 84% were living donors, 40% had DM, and 10% had DGF. At 90\u2010days post\u2010txp, the genotype guided cohort had an average of two fewer tacrolimus dose adjustments per patients (4\u00a0vs. 6,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001), spent longer time in therapeutic range (59%\u00a0vs. 47%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.004), and less time in concerning range (9%\u00a0vs. 18%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). Acute rejection, de novo donor specific antibodies, and eGFR was similar between the two cohorts. This matched cohort analysis assessing a genotype\u2010based dosing algorithm demonstrated improved LCP tac dosing efficiency. Patients on average, needed two fewer dose adjustments, spent longer time in therapeutic range and had significantly less time in concerning range.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70363","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:39:51Z","timestamp":1761896391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improved LCP Tacrolimus Dosing and Monitoring Outcomes With a Genotype\u2010Based Dosing Algorithm Versus Weight Based Dosing"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1623-0096","authenticated-orcid":false,"given":"Christine S.","family":"Wolesensky","sequence":"first","affiliation":[{"name":"Department of Pharmacy Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-9442","authenticated-orcid":false,"given":"Neha","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-4143","authenticated-orcid":false,"given":"Santosh","family":"Nagaraju","sequence":"additional","affiliation":[{"name":"Deaprtment of Transplant Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Hanish","sequence":"additional","affiliation":[{"name":"Deaprtment of Transplant Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Roberts","sequence":"additional","affiliation":[{"name":"Deaprtment of Transplant Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Dorsett","sequence":"additional","affiliation":[{"name":"Deaprtment of Transplant Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-4589","authenticated-orcid":false,"given":"David J.","family":"Taber","sequence":"additional","affiliation":[{"name":"Deaprtment of Transplant Surgery Medical University of South Carolina  Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v10.i5.90"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12790"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.113"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13691"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_278_20"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02912"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882\u2010023\u201003188\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.17"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001270"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15346"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001040"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14504"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912700022009143"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472\u20108206.2008.00644x"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:39:29Z","timestamp":1785443969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,31]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/ctr.70363"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70363","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,31]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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