{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:42:27Z","timestamp":1788270147068,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Proteinuria is a marker of kidney dysfunction and increased cardiovascular mortality. Sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated cardiorenal protection in chronic kidney disease, regardless of type 2 diabetes mellitus (T2DM) status. However, data evaluating SGLT2i impact on cardiorenal outcomes in kidney transplant recipients (KTRs) are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center, retrospective cohort study evaluated the safety and efficacy of SGLT2i therapy in adult KTRs transplanted between January 1, 2020 and December 31, 2023. Primary outcomes were changes in urine protein\u2010to\u2010creatinine ratio (UPCR) and urine albumin\u2010to\u2010creatinine ratio (UACR) at 1\u2010, 3\u2010, 6\u2010, and 12\u2010months post\u2010initiation. Secondary outcomes included changes in estimated glomerular filtration rate (eGFR), BMI, and hemoglobin A1c (HbA1c). Safety outcomes were cardiovascular hospitalization, acute kidney injury, urinary tract infection, and biopsy\u2010proven rejection within 12\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SGLT2i therapy was initiated in 77 KTRs, 524\u00a0days post\u2010transplant, predominantly in males (74.3%), African Americans (62.8%), and patients with T2DM (80.7%). Baseline UPCR and UACR were 0.387\u00a0g\/g and 302.2\u00a0mg\/g, respectively. No significant changes in UPCR, UACR, or eGFR were observed. Renal function was preserved at 12\u00a0months, with a transient decline at 1\u2010month that returned to baseline by 3\u00a0months. HbA1c and BMI remained stable. Few safety events occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In KTRs with moderate proteinuria, SGLT2i therapy was well tolerated with stable renal function over 12\u00a0months. A transient eGFR dip is consistent with patterns seen in non\u2010transplant populations. Absence of significant metabolic changes may reflect well\u2010controlled baseline parameters. Further studies are warranted to evaluate SGLT2i benefits in KTRs, especially in patients with higher grade proteinuria or early post\u2010transplant initiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70365","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:10:02Z","timestamp":1762276202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Sodium\u2010Glucose Cotransporter\u20102 Inhibitors on Proteinuria in Kidney Transplant Recipients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2477-4144","authenticated-orcid":false,"given":"Emili","family":"Anderson","sequence":"first","affiliation":[{"name":"UNC Medical Center  Chapel Hill North Carolina 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North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-205X","authenticated-orcid":false,"given":"Anita","family":"Yang","sequence":"additional","affiliation":[{"name":"UNC Medical Center  Chapel Hill North Carolina 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