{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:01:28Z","timestamp":1785445288483,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Extracorporeal cardiopulmonary resuscitation (ECPR) is a potentially life\u2010saving intervention in refractory out\u2010of\u2010hospital cardiac arrest (OHCA). ECPR enables, in most of the treated cases, ICU admission to patients who otherwise would have died at the emergency department (ED). Still, many of them die, frequently after withdrawal of life\u2010sustaining therapies due to irreversible critical conditions and related complications. The additional time provided by ECPR, however, might allow for the assessment of organ donor suitability. The aim of this study was to evaluate the impact of ECPR on the number of potential organ donors after refractory OHCA.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a post\u2010hoc analysis of the multicenter INCEPTION trial, which randomized 134 OHCA patients between conventional CPR (CCPR) and ECPR. Detailed patient reports were presented to transplant physicians to determine the acceptability of the liver and kidneys for organ donation.\u00a0In addition to the intention to treat analysis, we performed an \u201cas\u2010treated\u201d analysis, limited to patients arriving without return of spontaneous circulation (ROSC) at the ED.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of 70 patients randomized to ECPR and 64 to CCPR, potential organ donors were identified in 14 (20%) and 4 (6%) patients, respectively (\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n test,\n p<\/jats:italic>\n \u00a0=\u00a00.038). In the as\u2010treated analysis, 15 out of 55 (27%) treated with ECPR were potential donors, compared to 0 out of 59 treated with CCPR (\n p<\/jats:italic>\n \u00a0<\u00a00.001). This included five (9%) potential kidney donors and 15 (27%) potential liver donors.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Although ECPR is currently used with life\u2010saving intentions, it may simultaneously increase the number of potential organ donors following cardiac arrest in selected patients.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n ClinicalTrials.gov identifier: NCT03101787<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ctr.70382","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:39:14Z","timestamp":1763375954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organ Donor Potential After Extracorporeal Cardiopulmonary Resuscitation for Out\u2010of\u2010Hospital Cardiac Arrest: A Post\u2010Hoc Analysis of a Randomized Controlled Trial"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4471-6361","authenticated-orcid":false,"given":"Hanne C. R.","family":"Verberght","sequence":"first","affiliation":[{"name":"Department of Surgery Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"},{"name":"Institute For Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-7613","authenticated-orcid":false,"given":"Thijs S. R.","family":"Delnoij","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"},{"name":"Department of Cardiology Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-0492","authenticated-orcid":false,"given":"Martje M.","family":"Suverein","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Lunsing","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-2565","authenticated-orcid":false,"given":"Renicus C.","family":"Hermanides","sequence":"additional","affiliation":[{"name":"Department of Cardiology Isala Clinics Zwolle the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-8648","authenticated-orcid":false,"given":"Luuk","family":"Otterspoor","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Catharina Hospital Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5426-9334","authenticated-orcid":false,"given":"Carlos V.","family":"Elzo Kraemer","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Leiden University Medical Center Leiden University Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3453-7186","authenticated-orcid":false,"given":"Alexander P. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam University Medical Center location AMC University Amsterdam Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1730-3521","authenticated-orcid":false,"given":"Joris J.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Intensive Care University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-9524","authenticated-orcid":false,"given":"Erik","family":"Scholten","sequence":"additional","affiliation":[{"name":"Department of Intensive Care St. Antonius Hospital Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-2843","authenticated-orcid":false,"given":"Corstiaan A. den","family":"Uil","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Maasstad Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-7567","authenticated-orcid":false,"given":"Dinis dos Reis","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Erasmus Medical Center Erasmus University Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0700-1930","authenticated-orcid":false,"given":"Sakir","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Haga Hospital The Hague the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2575-694X","authenticated-orcid":false,"given":"Jesse de","family":"Metz","sequence":"additional","affiliation":[{"name":"Department of Intensive Care OLVG Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-8522","authenticated-orcid":false,"given":"Iwan C. C.","family":"van der Horst","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht the Netherlands"},{"name":"Albert Schweitzer Hospital Dordrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-6421","authenticated-orcid":false,"given":"Bas J.","family":"Mathot","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Erasmus Medical Center Erasmus University Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-027X","authenticated-orcid":false,"given":"Jeroen","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Surgery Erasmus Medical Center Erasmus University Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijntje W. N.","family":"Nijboer","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center Leiden University Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7900-5917","authenticated-orcid":false,"given":"Vincent E.","family":"de Meijer","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-3969","authenticated-orcid":false,"given":"Jan S. F.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3558-2277","authenticated-orcid":false,"given":"Maarten H. L.","family":"Christiaans","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-5533","authenticated-orcid":false,"given":"Arjan D.","family":"van Zuilen","sequence":"additional","affiliation":[{"name":"Department of Nephrology University Medical Center Utrecht Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"Hagenaars","sequence":"additional","affiliation":[{"name":"Organ Donation Coordinator Erasmus Medical Center Erasmus University Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6816-0268","authenticated-orcid":false,"given":"Jentina","family":"Wind","sequence":"additional","affiliation":[{"name":"Organ Donation Coordinator Maastricht University Medical Centre Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Danhof","sequence":"additional","affiliation":[{"name":"Organ Donation Coordinator University Medical Center Groningen University of Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5202-9345","authenticated-orcid":false,"given":"Steven W. M.","family":"Olde Damink","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"},{"name":"Institute For Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht the Netherlands"},{"name":"Department of General Visceral Vascular and Transplant Surgery University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-6228","authenticated-orcid":false,"given":"Bjorn","family":"Winkens","sequence":"additional","affiliation":[{"name":"Department of Methodology & Statistics Maastricht University Maastricht the Netherlands"},{"name":"Care and Public Health Research Institute Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3230-7712","authenticated-orcid":false,"given":"Jos G.","family":"Maessen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-2045","authenticated-orcid":false,"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Maastricht the Netherlands"},{"name":"Department of Cardiothoracic Surgery Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-4063","authenticated-orcid":false,"given":"Marcel C. G.","family":"van de Poll","sequence":"additional","affiliation":[{"name":"Department of Surgery Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"},{"name":"Institute For Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University Maastricht the Netherlands"},{"name":"Department of Intensive Care Medicine Maastricht University Medical Center+ Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the INCEPTION\u2010investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"C. F.HV O.Chastel P.Sutter et\u00a0al.Thematic Network on Improving Organ Donation and Transplantation in the EU\u2014Joint Statement. European kidney health alliance.2019."},{"issue":"5","key":"e_1_2_11_3_1","first-page":"2893","article-title":"Categories of Non\u2010Heart\u2010Beating Donors","volume":"27","author":"Kootstra G.","year":"1995","journal-title":"Transplantation Proceedings"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13506"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000001102"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2022.07.038"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2019.10.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001125"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.1025"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204511"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32338-2"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.11.011"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.109993"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.12.008"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.109883"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2024.110357"},{"issue":"6","key":"e_1_2_11_17_1","first-page":"484","article-title":"Cost\u2010Effectiveness of ECPR Versus CCPR in OHCA; a Pre\u2010Planned, Trial\u2010Based Economic Evaluation","volume":"13","author":"Delnoij T. S. R.","year":"2024","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2023.110035"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000984"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03271-0"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00298-8"},{"issue":"20","key":"e_1_2_11_22_1","first-page":"1916","article-title":"Extracorporeal CPR for Out\u2010of\u2010Hospital Cardiac Arrest","volume":"388","author":"Suverein M. M.","year":"2023","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003540"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:39:19Z","timestamp":1785443959000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/ctr.70382"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70382","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70382"}}