{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:04:52Z","timestamp":1773000292024,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Sarcopenia and frailty are common among kidney transplant candidates and often persist even after transplantation. Exercise therapy initiated during the perioperative period may improve physical function, but its benefits remain underexplored.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a single\u2010center prospective observational study evaluating a structured rehabilitation protocol in kidney transplant recipients. Patients received supervised exercise therapy starting from postoperative day (POD) 2, followed by resistance training and aerobic exercise during hospitalization. Upon discharge, participants were instructed to continue monthly supervised training sessions. Outcomes including skeletal muscle index (SMI), handgrip strength, gait speed, anaerobic threshold VO\n 2<\/jats:sub>\n , and peak VO\n 2<\/jats:sub>\n were assessed before transplant and at 1 year post\u2010transplant. Improvement rates were compared between patients who received rehabilitation and those who did not, and further among those who continued post\u2010discharge training.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients in the rehabilitation group showed significantly greater improvements in grip strength, gait speed, and VO\n 2<\/jats:sub>\n parameters compared to the control group (\n p<\/jats:italic>\n \u00a0<\u00a00.05). Among the rehabilitation group, those who continued training post\u2010discharge for \u22656 months exhibited the most pronounced improvements. No adverse effects on renal function were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Early and sustained rehabilitation is effective and safe for improving physical function in kidney transplant recipients. Incorporating structured exercise therapy into routine perioperative and post\u2010discharge care may enhance recovery and clinical outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ctr.70405","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T18:39:59Z","timestamp":1764441599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Perioperative Rehabilitation on Physical Function in Kidney Transplant Recipients"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2050-886X","authenticated-orcid":false,"given":"Masaaki","family":"Yanishi","sequence":"first","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Kimura","sequence":"additional","affiliation":[{"name":"Kidney Center Kansai Medical University Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Koito","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Taniyama","sequence":"additional","affiliation":[{"name":"Kidney Center Kansai Medical University Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology Kansai Medical University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508576"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"49","article-title":"Factors Associated With the Development of Sarcopenia in Kidney Transplant Recipients","volume":"49","author":"Yanishi M.","year":"2017","journal-title":"Transplantation Proceedings"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334732"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12992"},{"issue":"1","key":"e_1_2_12_6_1","first-page":"S1","article-title":"KDIGO Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation","volume":"10","author":"KDIGO Transplant Work Group","year":"2020","journal-title":"Kidney International Supplements"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12921118"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac159"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-019-01835-1"},{"issue":"3","key":"e_1_2_12_10_1","first-page":"3854","article-title":"Cardiopulmonary Exercise Testing in Patients After Kidney Transplantation","volume":"88","author":"Habedank 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