{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:58:10Z","timestamp":1790114290298,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1403\u20101\u2010107\u201071348"],"award-info":[{"award-number":["1403\u20101\u2010107\u201071348"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cyclosporine A (CsA) is used as graft\u2010versus\u2010host disease (GVHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (HSCT). While polymorphisms in CYP3A4, CYP3A5, and ABCB1 genes influence CsA metabolism, their role in HSCT remains underexplored. We investigated the impact of these polymorphisms on CsA pharmacokinetics, early toxicity, and clinical outcomes in 86 leukemia patients undergoing HSCT (IR.TUMS.HORCSCT.REC.1402.07). CsA levels were monitored via radioimmunoassay, and genotyping for CYP3A4, CYP3A5, and ABCB1 polymorphisms was done using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP). Carriers of the rs2740574 (CYP3A4*1B, \u2212392A&gt;G) and the rs776746 (CYP3A5*3, 6986A&gt;G) exhibited significantly higher mean trough concentrations compared to the wild\u2010type genotypes (112.6\u00a0\u00b1\u00a052.1\u00a0versus 75.6\u00a0\u00b1\u00a031.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003, 126.1\u00a0\u00b1\u00a055.0 versus 89.5\u00a0\u00b1\u00a041.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001, respectively). No significant difference was observed for the rs1045642 variants. Both rs776746 and rs2740574 variants were associated with increased markers of nephrotoxicity and hepatotoxicity within 3 days post\u2010HSCT. None of these polymorphisms showed significant associations with transplant outcomes. In conclusion, patients carrying rs776746 or rs2740574 achieved higher CsA trough levels and may require lower initial dosing. Future research should assess whether genotype\u2010guided CsA dosing improves achieving therapeutic levels and reduces early toxicity or suboptimal immunosuppression post\u2010HSCT.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70413","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:31:50Z","timestamp":1765377110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of CYP3A4, CYP3A5, and ABCB1 Polymorphisms on Cyclosporine Concentration in Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1111","volume":"39","author":[{"given":"Zahra","family":"Salehi","sequence":"first","affiliation":[{"name":"Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"},{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9057-1680","authenticated-orcid":false,"given":"Amirhossein","family":"Shahsavand","sequence":"additional","affiliation":[{"name":"Hematologic Malignancies Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"},{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mehdi","family":"Naghizadeh","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Fasa University of Medical Sciences  Fasa Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molouk","family":"Hadjibabaie","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahrbano","family":"Rostami","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habibeh","family":"Ghadimi","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Shamshiri","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Alimoghaddam","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Rabianataj","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardeshir","family":"Ghavamzadeh","sequence":"additional","affiliation":[{"name":"Hematology, Oncology and Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8677-0820","authenticated-orcid":false,"given":"Mohammadreza","family":"Ostadali Dehaghi","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center Research Institute for Oncology Hematology and Cell Therapy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Cyclosporine","author":"Tapia 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