{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:00:32Z","timestamp":1776254432806,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mycophenolic acid (MPA) is a common immunosuppressant used in children post\u2010orthotopic heart transplant (OHT). Multiple MPA dosing strategies exist, with limited reports of comparisons between dosing strategies and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective review of heart transplant recipients \u2264\u00a021 years from 2014 to 2022, comparing dose concordance and clinical outcomes of weight\u2010based mycophenolate dosing (15\u00a0mg\/kg\/dose every 12\u00a0h) to body surface area (BSA)\u2010based dosing (600\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/dose every 12\u00a0h).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed 109 patients total (56% in the BSA\u2010based cohort and 44% in the weight\u2010based cohort). The BSA\u2010based cohort received a higher total milligram dose (480 (IQR 200\u2013563) vs. 636 (IQR 320\u20131000),\n                      <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                      0.005), mg\/kg dose (14.5 (IQR 13.7\u201316.1) vs. 20.7 (IQR 16.4\u201325.8),\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      0.001) and mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      dose (382 (IQR 333\u2013470) vs. 596 (IQR 572\u2013612),\n                      <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                      0.001) compared to the weight\u2010based cohort. The BSA\u2010based cohort experienced a lower hazard of rejection (HR 0.2, 95% CI 0.1\u20130.4\u00a0vs. weight\u2010based) and a greater hazard for overall infection (HR 2.2, 95% CI 1.2\u20133.9). There was no significant difference in 1\u2010year post\u2010transplant mortality and incidence of post\u2010transplant lymphoproliferative disorder (PTLD).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates the discordance between two common mycophenolate dosing strategies (1200\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/day vs. 30\u00a0mg\/kg\/day) and its resultant impact on pediatric heart transplant\u2010related outcomes. Further multicenter data would be useful to elucidate the impact on post\u2010heart transplant morbidity and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70422","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:51:33Z","timestamp":1767099093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Mycophenolate Dosing Strategies in Pediatric Heart Transplant"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-4068","authenticated-orcid":false,"given":"Dawn Y.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Pharmacy Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-4996","authenticated-orcid":false,"given":"Anastacia","family":"Serluco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1215-7390","authenticated-orcid":false,"given":"Justin K.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-6972","authenticated-orcid":false,"given":"Gwen","family":"Nance","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-3519","authenticated-orcid":false,"given":"Zeling","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8633-5420","authenticated-orcid":false,"given":"Arene","family":"Butto","sequence":"additional","affiliation":[{"name":"Division of Cardiology Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"issue":"10","key":"e_1_2_8_2_1","first-page":"1015","article-title":"International Society for Heart and Lung Transplantation (ISHLT)","volume":"38","author":"Khush K. K.","year":"2019","journal-title":"Journal of Heart and Lung Transplantation"},{"key":"e_1_2_8_3_1","volume-title":"Cellcept [package insert]","year":"2018"},{"key":"e_1_2_8_4_1","volume-title":"Myfortic [package insert]","year":"2009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.005002112.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-6909-6_28"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-018-0234-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000871"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-023-00595-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2023.02.002"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13750"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181b7a9d0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00305-9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12695"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V133759"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.12.009"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-29.3.299"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70422","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70422","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:09:42Z","timestamp":1776251382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ctr.70422"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70422","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]},"assertion":[{"value":"2025-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70422"}}