{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:06:01Z","timestamp":1790028361703,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Primary sclerosing cholangitis recurrence (rPSC) after liver transplantation (LT) is common; however, the factors contributing to rPSC are poorly understood. This study aimed to identify the risk factors for rPSC after LT and determine whether donor type affects rPSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multicenter retrospective cohort analysis was conducted on 174 patients with PSC who underwent LT between January 2000 and January 2024. Multivariable Cox models were used to evaluate risk factors for rPSC. The rPSC risk for living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) recipients was compared using Kaplan\u2010Meier survival curves and log\u2010rank tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 174 recipients, 144 (83%) underwent LDLT and 30 (17%) underwent DDLT. Sixty\u2010four (37%) had inflammatory bowel disease (IBD) prior to LT. Thirty\u2010three patients (19%) had rPSC after LT. The median time to rPSC was 28 months (IQR 6\u2010252). Patients with rPSC were younger at the time of PSC diagnosis, and had a higher prevalence of biliary complications after LT and concomitant IBD than those without recurrence. Multivariable Cox regression identified LDLT (HR 3.92, 95% CI 1.06\u201314.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041), biliary complications (HR 2.18, 95% CI 1.05\u20134.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.037), IBD (HR 2.42, 95% CI 1.20\u20134.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.013), and acute cellular rejection (HR 2.43, 95% CI 1.08\u20135.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.032) as independent risk factors for rPSC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multicenter study identified LDLT, acute cellular rejection, IBD, and biliary complications as independent risk factors for rPSC. These findings underscore the need for individualized post\u2010transplant surveillance and provide important considerations for graft selection and perioperative management in patients with PSC, particularly in settings where LDLT is predominant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70436","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:27:14Z","timestamp":1767698834000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk Factors for Primary Sclerosing Cholangitis Recurrence Following Liver Transplantation: A Multicenter Retrospective Analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-0304","authenticated-orcid":false,"given":"Gupse","family":"Adali","sequence":"first","affiliation":[{"name":"Umraniye Training and Research Hospital University of Health Sciences  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8086-0956","authenticated-orcid":false,"given":"Sencan","family":"Acar","sequence":"additional","affiliation":[{"name":"Florence Nightingale Hospital Istanbul Bilim University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-147X","authenticated-orcid":false,"given":"Murat","family":"Harputluo\u011flu","sequence":"additional","affiliation":[{"name":"School of Medicine In\u00f6n\u00fc University  Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-7783","authenticated-orcid":false,"given":"Tongu\u00e7 Utku","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"School of Medicine Ac\u0131badem University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-947X","authenticated-orcid":false,"given":"Hamdi","family":"Karakayal\u0131","sequence":"additional","affiliation":[{"name":"School of Medicine Ac\u0131badem University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2961-2660","authenticated-orcid":false,"given":"Z\u00fclal","family":"Istemihan","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-249X","authenticated-orcid":false,"given":"Sabahattin","family":"Kaymako\u011flu","sequence":"additional","affiliation":[{"name":"Istanbul Faculty of Medicine Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0794-2741","authenticated-orcid":false,"given":"\u00c7i\u011fdem","family":"Ar\u0131kan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition Ko\u00e7 University School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-8540","authenticated-orcid":false,"given":"Murat","family":"Aky\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ko\u00e7 University School of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-3089","authenticated-orcid":false,"given":"Nilay","family":"Dani\u015f","sequence":"additional","affiliation":[{"name":"School of Medicine Dokuz Eyl\u00fcl University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1507-1851","authenticated-orcid":false,"given":"Mehmet","family":"Ak\u00e7a","sequence":"additional","affiliation":[{"name":"School of Medicine Dokuz Eyl\u00fcl University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-948X","authenticated-orcid":false,"given":"Mesut","family":"Akarsu","sequence":"additional","affiliation":[{"name":"School of Medicine Dokuz Eyl\u00fcl University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-7237","authenticated-orcid":false,"given":"Dilara","family":"Turan G\u00f6k\u00e7e","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-781X","authenticated-orcid":false,"given":"Derya","family":"Ar\u0131","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-2542","authenticated-orcid":false,"given":"Meral","family":"Akdo\u011fan Kayhan","sequence":"additional","affiliation":[{"name":"Ankara Bilkent City Hospital University of Health Sciences  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5846","authenticated-orcid":false,"given":"Haydar","family":"Adan\u0131r","sequence":"additional","affiliation":[{"name":"School of Medicine Akdeniz University  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-3971","authenticated-orcid":false,"given":"Din\u00e7","family":"Din\u00e7er","sequence":"additional","affiliation":[{"name":"School of Medicine Akdeniz University  Antalya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-5406","authenticated-orcid":false,"given":"Elvan","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"School of Medicine Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-1965","authenticated-orcid":false,"given":"\u0130lker","family":"Turan","sequence":"additional","affiliation":[{"name":"School of Medicine Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-7511","authenticated-orcid":false,"given":"Fulya","family":"G\u00fcn\u015far","sequence":"additional","affiliation":[{"name":"School of Medicine Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-3002","authenticated-orcid":false,"given":"Volkan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"School of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5663-0683","authenticated-orcid":false,"given":"Hale","family":"G\u00f6kcan","sequence":"additional","affiliation":[{"name":"School of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-7944","authenticated-orcid":false,"given":"Zeki","family":"Karasu","sequence":"additional","affiliation":[{"name":"School of Medicine Ege University  \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-5472","authenticated-orcid":false,"given":"Ramazan","family":"Idilman","sequence":"additional","affiliation":[{"name":"School of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i1.1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.05.011"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2023.07.009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15148"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16864"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290427"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad276"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.14744\/hf.2023.2023.0010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.liver.2023.100186"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2010.03402.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24496"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15148"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13852"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12082807"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24496"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/LVT.0000000000000523"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2008.02440.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14393"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i28.3171"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2022.100599"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:08:59Z","timestamp":1776251339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ctr.70436"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70436","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70436"}}