{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:00:25Z","timestamp":1776254425792,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the association between induction type and long\u2010term outcomes in kidney retransplant recipients who experienced graft loss due to BK virus\u2013associated nephropathy (BKVAN). Using Scientific Registry of Transplant Recipients data (2003\u20132021), we identified 277 adult kidney\u2010alone retransplant recipients with BKVAN\u2010related graft loss and categorized them by induction regimen: depletional (\n                    <jats:italic>n<\/jats:italic>\n                    = 217) and nondepletional (\n                    <jats:italic>n<\/jats:italic>\n                    = 60). The groups were similar overall, except the nondepletional cohort had lower panel\u2010reactive antibodies, a shorter time between transplants, and more live donor kidneys. Kaplan\u2013Meier curves assessed 10\u2010year recipient and graft survival, and Cox proportional hazards models, adjusted for key donor and recipient factors, evaluated associations between induction type and outcomes. Rates of delayed graft function, one\u2010year rejection, and estimated glomerular filtration rate were comparable between groups. Ten\u2010year recipient and death\u2010censored graft survival did not differ by induction type (recipient survival: HR 1.09; 95% CI 0.43\u20132.77;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.85; graft survival: HR 0.85; 95% CI 0.24\u20132.97;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.79). Recurrent BKVAN\u2010related graft failure occurred only in the depletional group (5 of 217; 2.3%), while rejection\u2010related graft failure was more common in the nondepletional group (5 of 60; 8.3%\u00a0vs. 6 of 217; 2.8%). Although these differences did not translate into long\u2010term graft survival disparities, they highlight the competing risks of viral recurrence and rejection. Thus, clinicians should interpret these results with caution and weigh the risks and benefits of induction choice in retransplant recipients with prior BKVAN, recognizing that this observational study cannot establish causality.\n                  <\/jats:p>","DOI":"10.1111\/ctr.70446","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T07:41:56Z","timestamp":1767944516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induction Regimens and Kidney Re\u2010Transplant Outcomes after BK Nephropathy\u2013Related Graft Loss: A U.S. Cohort Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-2288","authenticated-orcid":false,"given":"Rasha","family":"El\u2010Rifai","sequence":"first","affiliation":[{"name":"Division of Renal Diseases and Hypertension Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Fontana","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Jackson","sequence":"additional","affiliation":[{"name":"Complex Care Analytics M Health Fairview  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-2437","authenticated-orcid":false,"given":"Byron H.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-8607","authenticated-orcid":false,"given":"Amir Hossein","family":"Shams","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Quintiliano","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8495-9782","authenticated-orcid":false,"given":"Andrew J.","family":"Bentall","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"},{"name":"The William J von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund R.","family":"Razonable","sequence":"additional","affiliation":[{"name":"The William J von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"},{"name":"Division of Public Health Department of Medicine Infectious Diseases, and Occupational Medicine, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Kandaswamy","sequence":"additional","affiliation":[{"name":"Division of Transplant Surgery Department of Surgery University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5737-9742","authenticated-orcid":false,"given":"Samy M.","family":"Riad","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Mayo Clinic  Rochester Minnesota USA"},{"name":"The William J von Liebig Center For Transplantation and Clinical Regeneration Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e31822d08c1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14081616"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2020.06.015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001066"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13880"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2019.02.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13528"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12110"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2011.05.002"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2011.03891.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01972"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-201211271-01895"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2005.00759.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03083.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00074-16"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182921995"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05691207"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac071"},{"key":"e_1_2_11_21_1","first-page":"1535","volume-title":"Second Kidney Transplant Outcomes in Dialysis Dependent Recipients by Induction Type in the United States","author":"Swanson K. J.","year":"2023"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2021.07.047"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3397751"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000507"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8132672"},{"key":"e_1_2_11_26_1","unstructured":"J.Chapman P.O'Connell K.Kable B.Nankivell J.Renthawa andR.Sharma BK virus nephropathy: histological evolution by sequential pathology.2017."},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14314"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13194"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13216"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:09:31Z","timestamp":1776251371000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/ctr.70446"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70446","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70446"}}