{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:00:29Z","timestamp":1776254429698,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23 HL150280"],"award-info":[{"award-number":["K23 HL150280"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL087115"],"award-info":[{"award-number":["R01 HL087115"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL155821"],"award-info":[{"award-number":["R01 HL155821"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24 HL115354"],"award-info":[{"award-number":["K24 HL115354"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01 HL145435"],"award-info":[{"award-number":["U01 HL145435"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007891"],"award-info":[{"award-number":["T32 HL007891"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL174231"],"award-info":[{"award-number":["K24HL174231"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72\u00a0h after lung transplantation is associated with post\u2010transplant graft survival is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective cohort study of 1511 participants in the multi\u2010center Lung Transplant Outcomes Group cohort (2011\u20132018). Using Cox proportional hazards models and restricted mean survival time, we investigated whether IMV at 72\u00a0h was associated with post\u2010transplant graft survival. We secondarily evaluated whether IMV at 72\u00a0h was concordant with severe primary graft dysfunction (PGD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants requiring IMV at 72\u00a0h after transplant were sicker at transplantation (higher lung allocation score [LAS], increased extracorporeal membrane oxygenation, or IMV bridge) and more likely to have severe PGD. Use of IMV at 72\u00a0h was associated with 55% (95% CI 26%\u201392%) increased hazards of death or re\u2010transplantation after adjustment for age, ECMO, diagnosis, LAS, and intra\u2010operative transfusion. The association between IMV and graft survival was modified by severe PGD (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for interaction 0.002) but not by pre\u2010transplant ECMO (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for interaction 0.88) or pre\u2010transplant IMV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010for interaction 0.92). IMV was associated with increased risk of death or re\u2010transplantation among those with PGD (HR 2.35, 95% CI 1.43\u20133.85) but not among those without PGD (HR 1.04, 95% CI 0.77\u20101.41).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Requirement of IMV at 72\u00a0h is an important early post\u2010transplant outcome associated with post\u2010transplant survival. This appears driven by those with severe PGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70447","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:47:48Z","timestamp":1768384068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prolonged Invasive Mechanical Ventilation is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction: A Lung Transplant Outcomes Group Study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-0024","authenticated-orcid":false,"given":"Meghan","family":"Aversa","sequence":"first","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaf","family":"Keshavjee","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza","family":"Martinu","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Cypel","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew T.","family":"Sage","sequence":"additional","affiliation":[{"name":"University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-4637","authenticated-orcid":false,"given":"Joshua M.","family":"Diamond","sequence":"additional","affiliation":[{"name":"University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Glaxo\u2010Smith Kline  London 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