{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:43:51Z","timestamp":1784861031848,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010melanoma skin cancer (NMSC) is a frequent long\u2010term complication in transplant recipients, mainly due to chronic immunosuppression. Its incidence varies by transplant type and regimen, but existing evidence is often fragmented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess long\u2010term incidence and risk factors for NMSC, comparing transplant types, immunosuppressive regimens, and tumor subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort comprised 901 transplant recipients (1975\u20132024) who were under long\u2010term dermatologic follow\u2010up. Data on transplant type, immunosuppressive regimen\/duration, and tumor subtype were analyzed. NMSC\u2010free survival was evaluated with Kaplan\u2013Meier curves; Cox regression assessed predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 901 transplant recipients, 191 (21.2%) developed at least one NMSC during long\u2010term follow\u2010up. Crude incidence rates ranged between 1.88 and 2.68 per 100 person\u2010years across immunosuppressive drug classes and agents. In multivariable Cox models, older age at first transplant was independently associated with higher NMSC risk (HR 1.07 per year, 95% CI 1.06\u20131.09,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Sex, transplant group, and ever\u2010use of individual immunosuppressive agents were not significantly associated with NMSC risk after adjustment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this long\u2010term cohort, NMSC risk increased with age at first transplant, whereas transplant organ and ever\u2010use of major immunosuppressive agents were not independently associated in adjusted models. Over an extended follow\u2010up, NMSC accumulated steadily, with crude incidence rates around 1.88\u20132.68 cases per 100 person\u2010years across immunosuppressive classes and agents, underscoring the cumulative nature of skin cancer risk under chronic immunosuppression. Our results reinforce the need for sustained, long\u2010term dermatologic surveillance, particularly in older patients undergoing transplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70451","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:31:09Z","timestamp":1769783469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010Melanoma Skin Cancer in Transplant Recipients: A Single\u2010Centre Retrospective Cohort Study on the Role of Transplant Type, Immunosuppressive Exposure, and Tumor Subtypes"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3323-9216","authenticated-orcid":false,"given":"Corrado","family":"Zengarini","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Tagnin","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gioia","family":"Sorbi","sequence":"additional","affiliation":[{"name":"Plastic Surgery Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Guglielmo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Section of Dermatology and Infectious Diseases University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"La Placa","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Maria","family":"Piraccini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pileri","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Dermatology Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pignatti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"},{"name":"Plastic Surgery Unit IRCCS Azienda Ospedaliero\u2010Universitaria Di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"81","article-title":"Risks and Epidemiology of Infections After Hematopoietic Stem Cell Transplantation","author":"Gea\u2010Banacloche J.","year":"2016","journal-title":"Transplant Infectious Disease"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7313.600"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061224"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.3902"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004694"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15113"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160471"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6010006"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2014.08.005"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-56017-5_3"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12873"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.29252\/ibj.25.2.88"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12202441"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16173083"},{"key":"e_1_2_14_16_1","volume-title":"StatPearls","author":"Justiz Vaillant A. A.","year":"2025"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3750"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-40412-1"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12600"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23858.x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12669"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17371"},{"issue":"12","key":"e_1_2_14_23_1","first-page":"1268","article-title":"Initial Skin Cancer Screening for Solid Organ Transplant Recipients in the United States: Delphi Method Development of Expert Consensus Guidelines","volume":"32","author":"Crow L. D.","year":"2019","journal-title":"Transplant Infectious Diseases: The Official Journal of the Transplantation Society"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2019.08.005"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.09.68"},{"key":"e_1_2_14_26_1","article-title":"Post\u2010Kidney Transplant Cancer: A Real\u2010World Retrospective Analysis From a Single Italian Center","volume":"37","author":"Re Sart\u00f2 G. V.","year":"2024","journal-title":"Transplant Infectious Diseases: The Official Journal of the Transplantation Society"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2021.07.022"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2022.63.148"},{"issue":"1","key":"e_1_2_14_29_1","first-page":"157","article-title":"Nonmelanoma Skin Cancer in a Heart Transplant Patient: A Case Report and Review of the Literature","volume":"61","author":"Rude\u017e L. K.","year":"2022","journal-title":"Acta Clinica Croatica"},{"key":"e_1_2_14_30_1","first-page":"1","article-title":"Where There's Smoke, There's Fire \u2014 A Brief Report on Skin Malignancy Incidence in Renal, Heart, and Liver Transplant Recipients in Poland","author":"Wysocki W. M.","year":"2025","journal-title":"Oncology in Clinical Practice [Internet]"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.276"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1189680"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.02.804"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199003000-00006"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022137"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13978"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/88.1.17"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003773"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03320807"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:04:53Z","timestamp":1777410293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ctr.70451"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70451","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70451"}}