{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:20:24Z","timestamp":1773015624083,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Simultaneous liver\u2010kidney transplantation (SLKT) has been the standard of care for patients with end\u2010stage renal disease (ESRD) and primary hyperoxaluria type 1 (PH1). Lumasiran is a novel RNA interference (RNAi) therapy that targets glycolate oxidase and decreases oxalate production in the liver. Despite its availability, the use of RNAi with kidney transplant alone (KTA) for ESRD related to primary hyperoxaluria remains limited. We report a 39\u2010year\u2010old female with a history of KTA who presented with diarrhea and severe AKI. She rapidly progressed to anuria and allograft loss. Her kidney biopsy demonstrated calcium oxalate deposition. The patient was subsequently evaluated for a repeat kidney transplant. Given the morbidity associated with SLKT, RNAi therapy was pursued as an alternative. Initiation of Lumasiran reduced serum oxalate from 40 to 8\u00a0\u00b5mol\/L, enabling successful KTA with immediate graft function. At 12 months post\u2010transplant, renal function remained stable (creatinine 0.82\u00a0mg\/dL, serum oxalate &lt;1.5\u00a0\u00b5mol\/L). This case highlights RNAi therapy as a promising strategy to facilitate KTA in patients with PH1 and ESRD, potentially reducing the need for SLKT and its associated morbidity.<\/jats:p>","DOI":"10.1111\/ctr.70464","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:58:33Z","timestamp":1770238713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Successful Kidney Transplant\u2010Alone in Primary Hyperoxaluria Type 1 Using Lumasiran"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7047-4233","authenticated-orcid":false,"given":"Karen","family":"Flores","sequence":"first","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massini","family":"Merzkani","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Abdulkhalek","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Abuazzam","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Java","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowena","family":"Delos Santos","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Paul","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9580-3951","authenticated-orcid":false,"given":"Joseph","family":"Gaut","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Alhamad","sequence":"additional","affiliation":[{"name":"Division of Nephrology Washington University in St. Louis  St. Louis Missouri USA"},{"name":"Department of Pathology Washington University in St. Louis  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1301564"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.32"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35888"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2022.05.012"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.07.025"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000661\u20101"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2021.10.022"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac295"}],"container-title":["Clinical Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ctr.70464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ctr.70464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:22:04Z","timestamp":1773012124000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ctr.70464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/ctr.70464"],"URL":"https:\/\/doi.org\/10.1111\/ctr.70464","archive":["Portico"],"relation":{},"ISSN":["0902-0063","1399-0012"],"issn-type":[{"value":"0902-0063","type":"print"},{"value":"1399-0012","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70464"}}