{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:21:33Z","timestamp":1789413693956,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solid organ transplant (SOT) recipients face increased colorectal cancer (CRC) risk due to chronic immunosuppression and comorbidities such as primary sclerosing cholangitis, inflammatory bowel disease, and cystic fibrosis. Despite this elevated risk, CRC screening and treatment guidelines specific to transplant recipients remain limited. This systematic review and meta\u2010analysis evaluated the prevalence, clinical characteristics, risk factors, and outcomes of CRC in SOT recipients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search across major databases identified studies reporting CRC incidence and outcomes in kidney, liver, heart, and lung transplant recipients. Study quality was assessed using validated risk\u2010of\u2010bias tools. Pooled estimates were calculated using a random\u2010effects model; heterogeneity and organ\u2010specific subgroup analyses were also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pooled incidence of CRC in SOT recipients was 0.95% (95% CI: 0.35%\u20131.55%). Incidence was highest in heart transplant recipients (1.27%), followed by kidney (1.12%), lung (0.56%), and liver (0.53%) recipients. The mean time to CRC diagnosis was 8.8 years (95% CI: 5.94\u201311.82). A total of 41.13% of patients presented with stage III\/IV or metastatic disease, and right\u2010sided tumors predominated (46.34%). Surgical resection was performed in 62.74% of patients. The mortality rate among CRC patients post\u2010transplant was 61.13% (95% CI: 39.55%\u201382.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CRC in SOT recipients is associated with increased incidence, delayed diagnosis, and poor prognosis. The predominance of right\u2010sided tumors and late\u2010stage presentation underscore the need for tailored screening and surveillance protocols. Future clinical guidelines should incorporate organ\u2010specific risk stratification and long\u2010term monitoring to optimize outcomes in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70470","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:40:31Z","timestamp":1769784031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Risk Factors of Colorectal Cancer in Solid Organ Transplant Recipients: A Systematic Review and Meta Analysis"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6212-2458","authenticated-orcid":false,"given":"Jahnavi","family":"Udaikumar","sequence":"first","affiliation":[{"name":"Department of Medicine NYU Grossman School of Medicine  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesava Manikanta","family":"Achuta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Garden City Hospital  Garden USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vindhya Vasini","family":"Lella","sequence":"additional","affiliation":[{"name":"Konaseema Institute of Medical Sciences and Research Foundation  Amalapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rithish","family":"Nimmagadda","sequence":"additional","affiliation":[{"name":"Department of Medicine One Brooklyn Health  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satwik","family":"Kuppili","sequence":"additional","affiliation":[{"name":"Konaseema Institute of Medical Sciences and Research Foundation  Amalapuram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayanika","family":"Tummala","sequence":"additional","affiliation":[{"name":"Department of Medicine New York Medical College St. Mary's 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