{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:52:31Z","timestamp":1785423151226,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Transplantation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Antibodies to donor HLA (DSA) and non\u2010HLA antigens are associated with detrimental outcomes in kidney, heart, and lung transplants. Such data are scarce in liver transplants (LTx). We aim to study the roles of DSA and non\u2010HLA antibodies in T\u2010cell\u2010mediated rejection (TCMR) of LTx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Allograft biopsies (\n                      <jats:italic>n<\/jats:italic>\n                      = 103) from adult LTx recipients were studied. Biopsy\u2010paired serums were retrospectively tested for anti\u2010angiotensin II type 1 receptor (AT1R) and the Luminex panel of 60 non\u2010HLA Antibodies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TCMR was detected in 59 of 103 (57.3%) biopsies. Twenty\u2010six biopsies were categorized as moderate\u2010severe (MS\u2010TCMR), 77 as negative\u2010mild (NM\u2010TCMR). DSA was positive in 95\/103 (92.2%) cases and wasn't associated with MS\u2010TCMR. Anti\u2010AT1R antibodies were elevated in serum paired with MS\u2010TCMR vs. NM\u2010TCMR (18.8[15.2\u201340.0] vs. 13.0[10.0\u201321.5] U\/ml,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). Positive anti\u2010AT1R antibodies were associated with a higher incidence of MS\u2010TCMR (HR = 12.4[1.5\u2013101.6],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02). A panel of 18 non\u2010HLA Abs was significantly associated with MS\u2010TCMR. The number of panel\u201018 non\u2010HLA antibodies was higher with MS\u2010TCMR vs. NM\u2010TCMR (3[2\u20135] vs. 1[0\u20131],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The incidence of MS\u2010TCMR was higher in cases with panel\u201018 non\u2010HLA antibodies \u22653\u00a0vs. &lt;3 (HR = 19.6[6.0\u201364.8],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The frequency of MS\u2010TCMR was the highest when DSA, anti\u2010AT1R, and panel\u201018 non\u2010HLA antibodies were all present.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Non\u2010HLA antibodies to AT1R or the Luminex panel are associated with MS\u2010TCMR in LTx biopsies. The incidence of MS\u2010TCMR is higher when non\u2010HLA antibodies are present concomitantly with DSA, indicating an additive effect. Further studies are warranted to investigate the utility of routinely monitoring DSA and non\u2010HLA antibodies in LTx recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ctr.70480","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T17:24:27Z","timestamp":1771176267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Presence of Non\u2010HLA Antibody With DSA Is Associated With Moderate to Severe T Cell\u2010Mediated Rejection in Liver Transplant Recipients"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-1924","authenticated-orcid":false,"given":"Qingyong","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Transplant Pathology, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3666-7252","authenticated-orcid":false,"given":"Nigar A.","family":"Khurram","sequence":"additional","affiliation":[{"name":"Division of Transplant Pathology, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0029-6959","authenticated-orcid":false,"given":"Carol","family":"Bentlejewski","sequence":"additional","affiliation":[{"name":"Division of Transplant Pathology, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9582-3733","authenticated-orcid":false,"given":"Anthony J.","family":"Demetris","sequence":"additional","affiliation":[{"name":"Division of Transplant Pathology, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7540-5016","authenticated-orcid":false,"given":"Adriana","family":"Zeevi","sequence":"additional","affiliation":[{"name":"Division of Transplant Pathology, Department of Pathology University of Pittsburgh  Pittsburgh Pennsylvania 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